Summary of project PR001075

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001075. The data can be accessed directly via it's Project DOI: 10.21228/M8R97G This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001075
Project DOI:doi: 10.21228/M8R97G
Project Title:Targeted Sphingolipid analysis of human Fibroblasts silenced for or overexpressing GOLPH3
Project Summary:A group of sequentially-acting enzymes operating at the branchpoint among sphingolipid synthetic pathways binds the Golgi-localised oncoprotein GOLPH3. GOLPH3 sorts these enzymes into vesicles for intra-Golgi retro-transport, acting as a component of the cisternae inter-conversion mechanisms. Through these effects, GOLPH3 controls the sub-Golgi localisation, and the lysosomal degradation rate of specific enzymes. Here we evaluated the impact of overexpressing or silencing GOLPH3 on the sphingolipid composition of dermal human fibroblasts by targeted lipid analysis.
Institute:École polytechnique fédérale de Lausanne (EPFL)
Department:IBI
Laboratory:UPDANGELO
Last Name:D'Angelo
First Name:Giovanni
Address:Station 15 CH1015 Lausanne Switzerland
Email:giovanni.dangelo@epfl.ch
Phone:+41 216934276

Summary of all studies in project PR001075

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
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(* : Contains raw data)
ST001672 Targeted Sphingolipid analysis of human Fibroblasts silenced for or overexpressing GOLPH3 (part-I) Homo sapiens École polytechnique fédérale de Lausanne (EPFL) MS 2021-02-17 1 9 Uploaded data (81.2M)*
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