Summary of project PR001077
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001077. The data can be accessed directly via it's Project DOI: 10.21228/M8GT3N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001077 |
| Project DOI: | doi: 10.21228/M8GT3N |
| Project Title: | Untargeted phospholipid analysis of HeLa silenced for or overexpressing GOLPH3 |
| Project Summary: | A group of sequentially-acting enzymes operating at the branchpoint among sphingolipid synthetic pathways binds the Golgi-localised oncoprotein GOLPH3. GOLPH3 sorts these enzymes into vesicles for intra-Golgi retro-transport, acting as a component of the cisternae inter-conversion mechanisms. Through these effects, GOLPH3 controls the sub-Golgi localisation, and the lysosomal degradation rate of specific enzymes. Here we evaluated the impact of overexpressing or silencing GOLPH3 on the glycerophospholipid composition of HeLa cells by untargeted lipid analysis. |
| Institute: | École polytechnique fédérale de Lausanne (EPFL) |
| Department: | IBI |
| Laboratory: | UPDANGELO |
| Last Name: | D'Angelo |
| First Name: | Giovanni |
| Address: | Station 15, Lausanne, Vaud, 1015, Switzerland |
| Email: | giovanni.dangelo@epfl.ch |
| Phone: | +41 216934276 |
Summary of all studies in project PR001077
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001674 | Untargeted phospholipid analysis of HeLa silenced for or overexpressing GOLPH3 | Homo sapiens | École polytechnique fédérale de Lausanne (EPFL) | MS | 2021-02-26 | 1 | 6 | Uploaded data (66.5M)* |
