Summary of project PR001078
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001078. The data can be accessed directly via it's Project DOI: 10.21228/M8C111 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001078 |
| Project DOI: | doi: 10.21228/M8C111 |
| Project Title: | Quantitative analysis and genome-scale modeling of human CD4+ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways |
| Project Type: | MS: Targeted analysis |
| Project Summary: | This project is associated with five different studies(Part 1-5) and each study is associated with one dataset. All the datasets are submitted to Metabolomics Workbench. Part 1/5: It includes untargeted lipidomic analysis of CD4+ T-cell subsets (Th1,Th2,Th17 and iTreg cells) and their paired control (Th0) cells. Part 2/5: It includes quantitative targeted measurements of sphingolipids (ceramides and glycosphingolipids) in Th17, iTreg, and their paired control (Th0) cells. Part 3/5: It includes quantitative targeted measurements of sphingolipids (ceramides and glycosphingolipids) in Th17 cells before (scrambled / control) and after the triple knockdown of SPTLC1,2,3 genes (SPT de novo pathway: sphingolipid metabolism). Part 4/5: It includes quantitative targeted measurements of sphingolipids (ceramides, glycosphingolipids) in Th17 cells before (scrambled / control) and after the knockdown of UGCG gene (GCS pathway: sphingolipid metabolism). Part 5/5: It includes measurements of sphingolipids (sphingomyelins) in Th17 cells before (scrambled / control) and after the knockdown of UGCG gene(GCS pathway: sphingolipid metabolism). |
| Institute: | University of Turku |
| Department: | Systems Medicine |
| Laboratory: | Metabolomics |
| Last Name: | Sen |
| First Name: | Partho |
| Address: | Tykistökatu 6B, BioCity, 5th Floor, Turku, Southwest, 20521, Finland |
| Email: | partho.sen@utu.fi |
| Phone: | 0469608145 |
Summary of all studies in project PR001078
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001675 | Quantitative measurements of ceramides and glycosphingolipids in Th17 and iTreg cells (part-II) | Homo sapiens | University of Turku | MS | 2021-11-02 | 1 | 18 | Uploaded data (5.2M)* |
| ST001676 | Lipidomic analysis of CD4+ T-cell subsets (Th1,Th2,Th17 and iTreg cells) (part I) | Homo sapiens | University of Turku | MS* | 2021-11-02 | 1 | 46 | Uploaded data (822.9M)* |
| ST001677 | Quantitative targeted measurements of sphingolipids in Th17 cells before and after the triple knockdown of SPTLC1,2,3 genes (SPT, de novo pathway: sphingolipid metabolism) (part-III) | Homo sapiens | University of Turku | MS | 2021-11-02 | 1 | 6 | Uploaded data (578.1K)* |
| ST001678 | Quantitative measurements of sphingolipids in Th17 cells before and after the knockdown of UGCG gene (GCS pathway: sphingolipid metabolism) (part-IV) | Homo sapiens | University of Turku | MS | 2021-11-02 | 1 | 6 | Uploaded data (834.3K)* |
| ST001679 | Quantitative measurements of sphingomyelins in Th17 cells before and after the knockdown of UGCG gene (GCS pathway: sphingolipid metabolism) (part-V) | Homo sapiens | University of Turku | MS | 2021-11-02 | 1 | 6 | Uploaded data (167M)* |
