Summary of project PR001089
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001089. The data can be accessed directly via it's Project DOI: 10.21228/M8XT42 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001089 |
| Project DOI: | doi: 10.21228/M8XT42 |
| Project Title: | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice |
| Project Type: | Untargeted metabolomics |
| Project Summary: | Aging is associated with distinct phenotypical, physiological, and functional changes, leading to the onset of disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we performed physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that the decline in gait speed as a function of age and frailty is associated with dramatic increases in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their substrate selection and metabolism towards redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual and organ levels. |
| Institute: | National Institutes of Health |
| Department: | Experimental Gerontology Section and Translational Gerontology Branch |
| Laboratory: | NIA |
| Last Name: | de Cabo |
| First Name: | Rafael |
| Address: | 251 Bayview Blvd. Suite 100/Room 5C214. Baltimore, MD 21224 |
| Email: | deCaboRa@grc.nia.nih.gov |
| Phone: | 1-410-558-8510 |
| Funding Source: | Intramural Research Program of the National Institute on Aging, NIH |
Summary of all studies in project PR001089
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001699 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Muscle) part-I | Mus musculus | National Institutes of Health | MS | 2021-03-01 | 1 | 30 | Uploaded data (476.4M)* |
| ST001700 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Serum) part-II | Mus musculus | National Institutes of Health | MS | 2021-03-01 | 1 | 30 | Uploaded data (305.7M)* |
| ST001701 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Liver) part-III | Mus musculus | National Institutes of Health | MS | 2021-03-01 | 1 | 30 | Uploaded data (320.6M)* |
| ST001702 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Heart) part-IV | Mus musculus | National Institutes of Health | MS | 2021-03-01 | 1 | 30 | Uploaded data (313.8M)* |
| ST001703 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Brain) part-V | Mus musculus | National Institutes of Health | MS | 2021-03-01 | 1 | 29 | Uploaded data (274.5M)* |
