Summary of project PR001113
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001113. The data can be accessed directly via it's Project DOI: 10.21228/M8TX2D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001113 |
| Project DOI: | doi: 10.21228/M8TX2D |
| Project Title: | Examination of Candidate Differential Metabolites for Lethal Chlorpromazine Poisoning Using a LC-MS-based Metabolomics Approach in Mice |
| Project Type: | Original Research |
| Project Summary: | With the innovation of metabolite detection technology and the application of chemometrics in biomarker identification, metabolomics has been widely used to identify endogenous differential metabolites after drug poisoning. In this study, ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was combined with advanced chemometric approaches to identify differential metabolites that are associated with lethal chlorpromazine (CPZ) poisoning and associated perturbed metabolic pathways. Differential metabolite specificity and stability were assessed by comparing the CPZ samples to other antipsychotics, such as perphenazine (PER), clozapine (CLO) and olanzapine (OLA), that are associated with a high fatality frequency and by comparing them to non-drug related deaths (NDRDs) associated with hypoxia. The results implicated three candidate differential metabolites (acetyl-L-carnitine, propionyl-L-carnitine and succinic acid) with a high and relatively stable sensitivity (85.7–100%) following predictive analysis. Additionally, no differential metabolites were identified when comparing CPZ to PRE, OLA and CLO, but all of the drugs showed a similar pharmacodynamic receptor profile. Overall, this study provides a methodological and theoretical basis for biomarker identification in lethal CPZ poisoning (LCP) cases. |
| Institute: | new |
| Last Name: | Bai |
| First Name: | rui |
| Address: | Hebei Province, Shijiazhuang 050018, P.R. China |
| Email: | 15822925144@163.com |
| Phone: | 18522889554 |
Summary of all studies in project PR001113
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001739 | Differential Metabolites and Disturbed Metabolic Pathways Associated with chlorpromazine Poisoning | Mus musculus | Hebei medical university | MS | 2025-03-30 | 1 | 30 | Uploaded data (5.4G) |
| ST001746 | Examining the Identified Differential Metabolites in Other Antipsychotics with a High Fatality Frequency | Mus musculus | Hebei medical university | MS | 2025-03-30 | 1 | 80 | Uploaded data (14.1G)* |
| ST001781 | Identifying Candidate Differential Metabolites in lethal chlorpromazine poisoning Relative to non-drug related deaths (part III) | Mus musculus | Hebei medical university | MS | 2025-03-30 | 1 | 60 | Uploaded data (8.2G)* |
| ST001782 | Examining the Identified Differential Metabolites in Other Antipsychotics with a High Fatality Frequency (part IV) | Mus musculus | Hebei medical university | MS | 2025-03-30 | 1 | 80 | Not available |
| ST001783 | Performance of Three Differential Metabolites at Different TSS within 20 days | Mus musculus | Hebei medical university | MS | 2025-03-30 | 1 | 96 | Uploaded data (19.4G)* |
| ST001784 | Validation of the classifying model by OLA and CLO therapy cases | Mus musculus | Hebei medical university | MS | 2025-03-30 | 1 | 40 | Uploaded data (7.4G)* |
