Summary of project PR001120
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001120. The data can be accessed directly via it's Project DOI: 10.21228/M8XM6R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001120 |
| Project DOI: | doi: 10.21228/M8XM6R |
| Project Title: | Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis |
| Project Type: | targeted metabolomics |
| Project Summary: | Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented, and treated chronic immune-mediated colitis. Therapeutic application of GUT-108 reversed established colitis in a humanized chronic T cell-mediated mouse model. It decreased pathobionts while expanding resident protective bacteria; produced metabolites promoting mucosal healing and immunoregulatory responses; decreased inflammatory cytokines and Th-1 and Th-17 cells; and induced interleukin-10-producing colonic regulatory cells, and IL-10-independent homeostatic pathways. We propose GUT-108 for treating and preventing relapse for IBD and other inflammatory conditions characterized by unbalanced microbiota and mucosal permeability. |
| Institute: | University of North Carolina at Chapel Hill |
| Department: | UNC Departments of Medicine, Microbiology and Immunology, Center for Gastrointestinal Biology and Disease; UNC Department of Environmental Sciences and Engineering |
| Laboratory: | R. Balfour Sartor Lab; Kun Lu Lab |
| Last Name: | Lai |
| First Name: | Yunjia |
| Address: | 1104 MHRC, 135 Dauer Drive, NC |
| Email: | lai7@live.unc.edu |
| Phone: | 919-480-5489 |
| Funding Source: | Gusto Global LLC.; National Institute of Health (NIH) (grant no. P40OD010995; P30DK034987; P01DK094779); the Crohn’s and Colitis Foundation |
| Publications: | Nature Communications |
Summary of all studies in project PR001120
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001748 | Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis | Mus musculus | University of North Carolina at Chapel Hill | MS | 2021-04-30 | 1 | 287 | Uploaded data (2.2G)* |
