Summary of project PR001126
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001126. The data can be accessed directly via it's Project DOI: 10.21228/M8569X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001126 |
| Project DOI: | doi: 10.21228/M8569X |
| Project Title: | High-coverage metabolomics annotation uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication |
| Project Type: | untargeted metabolomics |
| Project Summary: | The mammalian gut harbors a complex and dynamic microbial ecosystem: the microbiota. While emerging studies support that microbiota regulates brain function with a few molecular cues suggested, the overall biochemical landscape of the “microbiota-gut-brain axis” remains largely unclear. Using high coverage metabolomics, we profiled feces, blood sera and cerebral cortical brain tissues of germ-free C57BL/6 mice and their age-matched conventionally raised counterparts. Results revealed for all three sample matrices metabolomic signatures owing to microbiota, yielding hundreds of identified metabolites including 533 altered for feces, 231 for sera and 58 for brain tissues with numerous significantly enriched pathways involving aromatic amino acids and neurotransmitters. Multicompartmental comparative analyses singled out microbiota-derived metabolites potentially implicated in interorgan transport and the gut-brain axis, exemplified by indoxyl sulfate and trimethylamine-N-oxide. Gender-specific characteristics of these landscapes were discussed. Our findings may be valuable for future research probing microbial influences on host metabolism and gut-brain communication. |
| Institute: | University of North Carolina at Chapel Hill |
| Department: | Department of Environmental Sciences and Engineering |
| Last Name: | Lai |
| First Name: | Yunjia |
| Address: | 1104 MHRC, 135 Dauer Dr., Chapel Hill, NC, 27599, USA |
| Email: | yunjia.lai@outlook.com |
| Phone: | 9194805489 |
| Funding Source: | NIEHS |
Summary of all studies in project PR001126
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001756 | Metabolomics of mouse feces comparing GF and CONV-R mice | Mus musculus | University of North Carolina at Chapel Hill | MS* | 2021-07-26 | 1 | 48 | Uploaded data (10.8G)* |
| ST001757 | Metabolomics of mouse blood sera comparing GF and CONV-R mice | Mus musculus | University of North Carolina at Chapel Hill | MS* | 2021-07-26 | 1 | 48 | Uploaded data (9.6G)* |
| ST001758 | Metabolomics of mouse cerebral cortical brain tissues comparing GF and CONV-R mice | Mus musculus | University of North Carolina at Chapel Hill | MS* | 2021-07-26 | 1 | 48 | Uploaded data (8.9G)* |
