Summary of project PR001136

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001136. The data can be accessed directly via it's Project DOI: 10.21228/M8VQ4D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001136
Project DOI:doi: 10.21228/M8VQ4D
Project Title:A scalable workflow for the human exposome
Project Type:Untargeted GC-MS quantitative analysis
Project Summary:Complementing the genome with an understanding of the human exposome is an important challenge for contemporary science and technology. Tens of thousands of chemicals are used in commerce, yet cost for targeted environmental chemical analysis limits surveillance to a few hundred known hazards. To overcome limitations which prevent scaling to thousands of chemicals, we developed a single-step express liquid extraction (XLE), gas chromatography high-resolution mass spectrometry (GC-HRMS) analysis and computational pipeline to operationalize the human exposome. We show that the workflow supports quantification of environmental chemicals in human plasma (200 µL) and tissue (≤ 100 mg) samples. The method also provides high resolution, sensitivity and selectivity for exposome epidemiology of mass spectral features without a priori knowledge of chemical identity. The simplicity of the method can facilitate harmonization of environmental biomonitoring between laboratories and enable population level human exposome research with limited sample volume.
Institute:Emory University
Department:Medicine, Pulmonary
Laboratory:Dean Jones
Last Name:Hu
First Name:Xin
Address:Emory University Whitehead building (Rm 225), 615 Michael Street, Atlanta, Georgia, 30322, USA
Email:xin.hu2@emory.edu
Phone:4047275091
Funding Source:This study was supported by the NIEHS, U2C ES030163 (DPJ), U2C ES030859 (DIW) and P30 ES019776 (CJM), NIDDK RC2 DK118619 (KNL), NHLBI R01 HL086773 (DPJ), US Department of Defense W81XWH2010103 (DPJ), and the Chris M. Carlos and Catharine Nicole Jockisch Carlos Endowment Fund in Primary Sclerosing Cholangitis (PSC) (KNL).
Contributors:Xin Hu, Douglas I. Walker, Yongliang Liang, M. Ryan Smith, Michael L. Orr, Brian D. Juran, Chunyu Ma, Karan Uppal, Michael Koval, Greg S. Martin, David C. Neujahr, Carmen J. Marsit, Young-Mi Go, Kurt Pennell, Gary W. Miller, Konstantinos N. Lazaridis, Dean P. Jones

Summary of all studies in project PR001136

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST001787 GC-XLE method development: dSPE and MgSO4 as clean-up for sample preparation Homo sapiens Emory University MS* 2021-05-21 1 82 Uploaded data (3.6G)*
ST001797 SRM1957 validation using GC-XLE Homo sapiens Emory University MS 2021-05-20 1 9 Uploaded data (360.2M)*
ST001798 SRM1957 validation using GC-XLE (2) Homo sapiens Emory University MS 2021-05-20 1 9 Uploaded data (423.8M)*
ST001799 Recovery of internal std in SRM-1957 Homo sapiens Emory University MS 2021-05-20 1 57 Uploaded data (2.7G)*
ST001800 CHDWB human plasma exposomics analysis - 2 Homo sapiens Emory University MS* 2021-05-28 1 66 Uploaded data (2.8G)*
ST001801 CHDWB human plasma exposomics analysis - 1 Homo sapiens Emory University MS 2021-05-28 1 203 Uploaded data (8.7G)*
ST001802 Human lung exposomics analysis Homo sapiens Emory University MS* 2021-05-28 1 27 Uploaded data (1.4G)*
ST001803 Human thyroid exposomics analysis Homo sapiens Emory University MS* 2021-05-28 1 20 Uploaded data (1G)*
ST001804 Human stool exposomics analysis Homo sapiens Emory University MS* 2021-05-28 1 28 Uploaded data (1G)*
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