Summary of project PR001137
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001137. The data can be accessed directly via it's Project DOI: 10.21228/M8R102 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001137 |
| Project DOI: | doi: 10.21228/M8R102 |
| Project Title: | Effect of external low-dose rate (LDR) radiation on mouse biofluid metabolomic |
| Project Summary: | An important component of ionizing radiation (IR) exposure after a radiological incident may include low-dose rate (LDR) exposures either externally or internally, such as from 137Cs deposition. LDR exposures can have different effects compared to acute high-dose rate exposures from a health and biodosimetry perspective. In this study, a novel irradiation system, VAriable Dose-rate External 137Cs irradiatoR (VADER), was used to expose male and female mice to a variable LDR over a 30-day time span to cumulative doses of 1 (only in males), 2, 2.8, 4.1, 8.8 (only in males), or 9.7 Gy to simulate fall-out type exposures. Urine and serum from mice exposed to an acute dose (~0.8 Gy/min) of x-rays were collected in parallel. Radiation markers were identified by global mass spectrometry based metabolomics and the machine learning algorithm Random Forests. |
| Institute: | Georgetown University |
| Last Name: | Pannkuk |
| First Name: | Evan |
| Address: | 3970 Reservoir Rd, NW New Research Building E504 |
| Email: | elp44@georgetown.edu |
| Phone: | 2026875650 |
Summary of all studies in project PR001137
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001790 | Effect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part I) | Mus musculus | Georgetown University | MS* | 2021-12-15 | 1 | 192 | Uploaded data (35.3G)* |
| ST001791 | Effect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part II) | Mus musculus | Georgetown University | MS* | 2021-12-15 | 1 | 182 | Uploaded data (45.8G)* |
| ST001792 | Effect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part III) | Mus musculus | Georgetown University | MS* | 2021-12-15 | 1 | 99 | Uploaded data (22.3G)* |
| ST001793 | Effect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part IV) | Mus musculus | Georgetown University | MS* | 2021-12-15 | 1 | 87 | Uploaded data (41G)* |
| ST001806 | Effect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part V) | Mus musculus | Georgetown University | MS* | 2021-12-15 | 1 | 99 | Uploaded data (22.3G)* |
