Summary of project PR001142
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001142. The data can be accessed directly via it's Project DOI: 10.21228/M8368X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001142 |
| Project DOI: | doi: 10.21228/M8368X |
| Project Title: | Impact of high intensity and moderate exercise on genomic and metabolic remodeling with age in male mice |
| Project Type: | Untargeted metabolomics |
| Project Summary: | How skeletal muscle adapts to different types of exercise intensity with age is not known. Young and old C57BL/6 male mice were assigned to either a sedentary or two types of exercise regimes consisting of daily high-intensity intermittent (HIIT) or moderate intensity continuous (MICT) training for 4 weeks, compatible with the older group’s exercise capacity. Body composition, fasting blood glucose levels, and muscle strength were improved in exercised old mice compared to sedentary controls, while the exercise benefits were absent in younger animals. Skeletal muscle exhibited structural and functional adaptations in response to exercise, as revealed by electron microscopy, OXPHOS assays, respirometry, and PGC-1? and LC3-II protein levels. Transcriptomics analysis of gastrocnemius muscle combined with liver and serum metabolomics unveiled an age-dependent metabolic remodeling provoked by exercise through mitochondrial biogenesis, energy metabolism, and cellular plasticity. These results are supportive of a tailored exercise prescription approach with the goal of improving health and ameliorating age-associated loss of muscle mass, strength and function in the elderly. |
| Institute: | National Institutes of Health |
| Department: | Experimental Gerontology Section and Translational Gerontology Branch, NIA |
| Last Name: | de Cabo |
| First Name: | Rafael |
| Address: | 251 Bayview Blvd. Suite 100/Room 5C214. Baltimore, MD 21224 |
| Email: | deCaboRa@grc.nia.nih.gov |
| Phone: | +1-410-558-8510 |
| Funding Source: | Intramural Research Program of the National Institute on Aging, NIH |
Summary of all studies in project PR001142
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001808 | Impact of high intensity and moderate exercise on genomic and metabolic remodeling with age in male mice | Mus musculus | National Institutes of Health | MS | 2021-09-15 | 1 | 108 | Uploaded data (1.1G)* |
