Summary of project PR001168

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001168. The data can be accessed directly via it's Project DOI: 10.21228/M8QT2F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001168
Project DOI:doi: 10.21228/M8QT2F
Project Title:Bile acid composition in Human fecal samples
Project Summary:Centenarians, or individuals who have lived more than a century, represent the ultimate model of successful longevity associated with decreased susceptibility to ageing-associated illness and chronic inflammation. The gut microbiota is considered to be a critical determinant of human health and longevity. Here we show that centenarians (average 107 yo) have a distinct gut microbiome enriched in microbes capable of generating unique secondary bile acids, including iso-, 3-oxo-, allo-, 3-oxoallo-, and isoallo-lithocholic acid (LCA), as compared to elderly (85-89 yo) and young (21-55 yo) controls.
Institute:Keio University
Department:School of Medicine
Laboratory:Dept of Microbiology and Immunology
Last Name:Atarashi
First Name:Koji
Address:35 Shinanomachi, Shinjuku-ku, Tokyo, JAPAN
Email:kojiatarashi@keio.jp
Phone:0353633769

Summary of all studies in project PR001168

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST001851 Quantitative analysis of bile acids in fecal samples from centenarians, elderly and young subjects. Homo sapiens Keio University School of Medicine MS 2021-07-07 1 387 Uploaded data (50.2M)*
ST001852 Screening of unique bile acid metabolizing bacteria Bacteria Keio University School of Medicine MS 2021-07-07 1 1044 Uploaded data (2.4G)*
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