Summary of project PR001196
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001196. The data can be accessed directly via it's Project DOI: 10.21228/M83X4N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001196 |
| Project DOI: | doi: 10.21228/M83X4N |
| Project Title: | Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress |
| Project Summary: | Amino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino acids remains poorly understood. Here, we show that a previously identified cellular structure, the mitochondrial-derived compartment (MDC), functions to protect cells from amino acid stress. In response to amino acid elevation, MDCs are generated from mitochondria, where they selectively sequester and deplete SLC25A nutrient carriers and their associated import receptor Tom70 from the organelle. Generation of MDCs promotes amino acid catabolism, and their formation occurs simultaneously with transporter removal at the plasma membrane via the multi-vesicular body (MVB) pathway. Combined loss of vacuolar amino acid storage, MVBs and MDCs renders cells sensitive to high amino acid stress. Thus, we propose that MDCs operate as part of a coordinated cell network that facilitates amino acid homoeostasis through post-translational nutrient transporter remodeling. |
| Institute: | University of Utah School of Medicine |
| Department: | Biochemistry |
| Laboratory: | Hughes Lab |
| Last Name: | Hughes |
| First Name: | Adam |
| Address: | 15 N Medical Drive East, RM 4100, Salt Lake City, UT, 84112, USA |
| Email: | hughes@biochem.utah.edu |
| Phone: | 8015812481 |
Summary of all studies in project PR001196
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001901 | Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress | Saccharomyces cerevisiae | University of Utah School of Medicine | MS | 2021-08-25 | 1 | 120 | Uploaded data (34.7G)* |
