Summary of project PR001218
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001218. The data can be accessed directly via it's Project DOI: 10.21228/M88H76 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001218 |
| Project DOI: | doi: 10.21228/M88H76 |
| Project Title: | Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype |
| Project Summary: | Urinary O-desmethylangolensin (ODMA) concentrations provide a functional gut microbiome marker of dietary isoflavone daidzein metabolism to ODMA. Individuals who do not have gut microbial environments that produce ODMA have less favorable cardiometabolic and cancer risk profiles. Urinary metabolomics profiles were evaluated in relation to ODMA metabotypes within and between individuals over time. Secondary analysis was conducted of data from the BEAN2 trial, which was a cross-over study of premenopausal women consuming six months on a high- and a low-soy diet, each separated by a 1-month washout period. In all of the 672 samples in the study, 66 of the 84 women had the same ODMA metabotype at seven or all eight time points. Two or four urine samples per woman were selected based on temporal metabotypes in order to compare within and across individuals. Metabolomics assays for primary metabolism and biogenic amines were conducted in 60 urine samples from 20 women. Partial least-squares discriminant analysis was used to compare metabolomics profiles. |
| Institute: | George Mason University |
| Last Name: | Frankenfeld |
| First Name: | Cara |
| Address: | 4400 University Drive, Fairfax, VA 22030 |
| Email: | prof.frankenfeld@gmail.com |
| Phone: | (206) 265-2563 |
| Funding Source: | Soy Health Research Program |
Summary of all studies in project PR001218
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001928 | Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype | Homo sapiens | George Mason University | MS | 2021-10-29 | 1 | 73 | Not available |
| ST001929 | Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype (Part 2) | Homo sapiens | George Mason University | MS | 2021-11-02 | 1 | 61 | Uploaded data (677.7M)* |
