Summary of project PR001258

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001258. The data can be accessed directly via it's Project DOI: 10.21228/M83M69 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001258
Project DOI:doi: 10.21228/M83M69
Project Title:Lipidomic characterization of Candida albicans in response to Aureobasidin treatment in vitro.
Project Summary:Candida albicans is an opportunistic yeast pathogen that causes a wide range of infections especially amongst immunocompromised patients. Aureobasidin A (AbA) has been shown to inhibit inositolphosphoryl ceramide synthase (IPCS), a key enzyme responsible for sphingolipid biosynthesis. There are limited studies exploring IPCS as a target molecule for antifungal treatment. It is hypothesized that the mechanism of AbA inhibition involves alteration of C. albicans phospholipid and sphingolipid profiles. The profiling of C. albicans phospholipid and sphingolipid upon exposure to 0.5-4 µg/ml of AbA were determined using Liquid chromatography-mass spectrometry (LC-MS).
Institute:University of Malaya
Department:Medical Microbiology Department
Laboratory:Lab 3
Last Name:Hamdan
First Name:Nur Wahida
Address:Jalan Profesor Diraja Ungku Aziz, 50603 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Email:nurwahidahamdan@siswa.um.edu.my
Phone:0193354272
Funding Source:FRGS(FP035-2014A), UM PPP(PG178-2015B)

Summary of all studies in project PR001258

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST001982 Lipidomic characterization of Candida albicans in response to Aureobasidin treatment in vitro. Candida albicans University of Malaya MS* 2021-11-22 1 80 Uploaded data (542.6K)
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