Summary of project PR001341
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001341. The data can be accessed directly via it's Project DOI: 10.21228/M8CM41 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001341 |
| Project DOI: | doi: 10.21228/M8CM41 |
| Project Title: | Comparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt based drugs |
| Project Summary: | Pt based drugs play a very important role in current cancer treatment; yet their cellular and mechanistic aspects are not fully understood. NMR metabolomics provides a powerful tool to investigate the metabolic perturbations induced by Pt drugs in cancer cells and decipher their meaning in relation to the presumed molecular mechanisms. We have carried out a systematic and comparative NMR metabolomics study to analyze the responses of A2780 human ovarian cancer cells to the main clinically established Pt drugs, i.e. cisplatin, carboplatin and oxaliplatin, with a particular attention for the oxaliplatin/cisplatin comparison in view of recently described mechanistic differences. Notably, NMR analysis revealed some moderate and consistent changes in the metabolomic profiles of A2780 cells treated with the 3 Pt drugs with respect to controls but only very small differences among them. Beyond the expected alterations at the level of the nucleic acids the observed changes highlight in all cases induction of a significant ER stress. Owing to the clinical relevance of platinum resistance the behavior of a cisplatin resistant A2780 cancer cell line upon cisplatin treatment was also evaluated. |
| Institute: | University of Florence |
| Department: | Department of Chemistry |
| Laboratory: | Metabolomics |
| Last Name: | Ghini |
| First Name: | Veronica |
| Address: | via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy |
| Email: | ghini@cerm.unifi.it |
| Phone: | +39 3922800462 |
Summary of all studies in project PR001341
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002116 | Comparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt based drugs | Homo sapiens | University of Florence | NMR* | 2022-10-03 | 1 | 60 | Uploaded data (108.1M)* |
