Summary of project PR001359
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001359. The data can be accessed directly via it's Project DOI: 10.21228/M8270X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001359 |
| Project DOI: | doi: 10.21228/M8270X |
| Project Title: | The Carbohydrate Sensing Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Dynamics and Progression of Diabetic Nephropathy |
| Project Type: | Biomarker under ChREBP controlled lipidome |
| Project Summary: | Despite recent advances, diabetic nephropathy (DN) remains a major public health concern. The precise underlying molecular mechanisms of DN remain elusive. Accumulating recent evidence suggests that mitochondrial integrity and lipid metabolism in podocytes significantly contribute to the pathogenesis of DN. However, the interplay between these two key metabolic regulators of DN is not fully understood. This study examines the role of ChREBP (carbohydrate-response element-binding protein), a master regulator of lipogenesis, on mitochondrial morphology and progression of DN. Our findings suggest that diabetic mice with podocyte-specific deletion of ChREBP are protected against mitochondrial fragmentation and progression of DN. Using liquid chromatography coupled with mass spectrometry, we identified the central role of ChREBP-induced plasmalogen phospholipids in linking mitochondrial lipidomes with mitochondrial dynamics in DN. |
| Institute: | University of Texas MD Anderson Cancer Center |
| Department: | Nephrology |
| Laboratory: | Danesh Laboratory |
| Last Name: | Danesh |
| First Name: | Farhad |
| Address: | 1515 Holcombe Blvd, Houston, TX77030 |
| Email: | fdanesh@mdanderson.org |
| Phone: | 7135634498 |
| Contributors: | Iqbal Mahmud, Philip L. Lorenzi |
Summary of all studies in project PR001359
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002145 | The Carbohydrate Sensing Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Dynamics and Progression of Diabetic Nephropathy | Mus musculus | University of Texas MD Anderson Cancer Center | MS | 2022-05-02 | 1 | 10 | Uploaded data (1.4G)* |
