Summary of project PR001376
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001376. The data can be accessed directly via it's Project DOI: 10.21228/M8VH8V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001376 |
| Project DOI: | doi: 10.21228/M8VH8V |
| Project Title: | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase |
| Project Summary: | Cancers disrupt host homeostasis in various manners but the identity of host factors underlying such disruption remains largely unknown. Here we show that nicotinamide-N-methyltransferase (NNMT) is a novel host factor that mediates metabolic dysfunction in the livers of cancer-bearing mice. Multiple solid cancers distantly increase expression of Nnmt and its product 1-methylnicotinamide (MNAM) in the liver. Multi-omics analyses reveal suppression of the urea cycle accompanied by accumulation of amino acids, and enhancement of uracil biogenesis in the livers of cancer-bearing mice. Importantly, genetic deletion of Nnmt leads to alleviation of these metabolic abnormalities, and buffers cancer-dependent weight loss and reduction of the voluntary wheel-running activity. Our data also demonstrate that MNAM is capable of affecting urea cycle metabolites in the liver. These results suggest that cancers up-regulate the hepatic NNMT pathway to rewire liver metabolism towards uracil biogenesis rather than nitrogen disposal via the urea cycle, thereby disrupting host homeostasis. |
| Institute: | Tohoku University |
| Last Name: | Kawaoka |
| First Name: | Shinpei |
| Address: | 4-1 Seiryo-cho, Sendai, Miyagi, 9808575, Japan |
| Email: | kawaokashinpei@gmail.com |
| Phone: | 0227178568 |
Summary of all studies in project PR001376
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002163 | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase | Mus musculus | Tohoku University | MS | 2022-05-27 | 1 | 37 | Uploaded data (33.2G)* |
| ST002167 | Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase (AML cells) | Mus musculus | Tohoku University | MS | 2022-06-01 | 1 | 17 | Uploaded data (15.6G)* |
