Summary of project PR001385

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001385. The data can be accessed directly via it's Project DOI: 10.21228/M8PT3H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001385
Project DOI:doi: 10.21228/M8PT3H
Project Title:Multiomics Analyses Reveal the Central Role of Pentose Phosphate Pathway in Resident Thymic Macrophages to Cope with Efferocytosis-Associated Stress
Project Summary:Tissue-resident macrophages (TRMs) are heterogeneous cell populations found throughout the body. Depending on their location, they perform diverse functions maintaining tissue homeostasis and providing immune surveillance. To survive and function within, TRMs adapt metabolically to the distinct microenvironments. However, little is known about the metabolic signatures of TRMs. The thymus provides a nurturing milieu for developing thymocytes yet efficiently removes those that failed the selection, relying on the TRMs – resident thymic macrophages (TMφs). This study harnesses multiomics analyses to characterize TMφs and unveils their unique metabolic features. We find that the pentose phosphate pathway (PPP) is preferentially activated in TMφs, responding to the reduction-oxidation demands associated with the efferocytosis of dying thymocytes. The blockade of PPP in Mφs leads to decreased efferocytosis, which can be rescued by ROS scavengers. Our study reveals the key role of PPP in TMφs and underscores the importance of metabolic adaptation in supporting Mφ efferocytosis.
Institute:National Yang Ming Chiao Tung University
Department:Institute of Microbiology and Immunology
Laboratory:Chia-Lin Hsu
Last Name:Chia-Lin
First Name:Hsu
Address:R309, Biomedical Building, NYCU, No. 155, Sec. 2, Linong St., Beitou Dist. Taipei 112, Taiwan
Email:clhsu@nycu.edu.tw
Phone:+886-2-2826-7000 ext: 65619
Publications:Tsai TL, Zhou TA, Hsieh YT, Wang JC, et al. Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress. Cell Rep 2022 Jul 12;40(2):111065. PMID: 35830797 https://doi.org/10.1016/j.celrep.2022.111065
Contributors:Tsung-Lin Tsai, Ju-Chu Wang, Chen-Hua Huang, Chao-Hsiung Lin, Chia-Lin Hsu

Summary of all studies in project PR001385

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ST002177 Multiomics Analyses Reveal the Central Role of Pentose Phosphate Pathway in Resident Thymic Macrophages to Cope with Efferocytosis-Associated Stress Mus musculus National Yang Ming Chiao Tung University MS* 2022-06-09 1 21 Uploaded data (18.1M)*
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