Summary of project PR001393
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001393. The data can be accessed directly via it's Project DOI: 10.21228/M8NT4K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001393 |
| Project DOI: | doi: 10.21228/M8NT4K |
| Project Title: | An early-life microbiota metabolite protects against obesity via intestinal PPAR-Gamma |
| Project Type: | Untargeted Metabolomics analysis |
| Project Summary: | The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to antibiotics and a high-fat diet, we show that Lactobacillus species, predominant members of the small intestine microbiota, regulate intestinal epithelial cells (IECs) to limit diet-induced obesity during early-life. A Lactobacillus-derived metabolite, phenyllactic acid (PLA), protected against metabolic dysfunction caused by early-life exposure to antibiotics and a high-fat diet by increasing the abundance of peroxisome proliferator activated receptor gamma (PPAR-gamma) in the small intestine IECs. Therefore, PLA is a microbiota-derived metabolite that activates protective pathways in the small intestine epithelium to regulate fat absorption and prevent obesity during early life. |
| Institute: | Vanderbilt University |
| Department: | Chemistry |
| Laboratory: | Center for Innovative Technology |
| Last Name: | Codreanu |
| First Name: | Simona Gabriella |
| Address: | 1234 Stevenson Center Lane |
| Email: | SIMONA.CODREANU@VANDERBILT.EDU |
| Phone: | 16158758422 |
Summary of all studies in project PR001393
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002186 | An early-life microbiota metabolite protects against obesity via intestinal PPAR-gamma | Mus musculus | Vanderbilt University | MS* | 2023-06-06 | 1 | 20 | Uploaded data (5.2G)* |
