Summary of project PR001397
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001397. The data can be accessed directly via it's Project DOI: 10.21228/M84T4X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001397 |
| Project DOI: | doi: 10.21228/M84T4X |
| Project Title: | The effects of obesity microbiota on colorectal carcinogenesis in murine models |
| Project Summary: | Obesity is a risk factor for colorectal cancer (CRC). We aim to study the effects and mechanisms of gut microbiota of obese subjects in contributing to CRC progression. Conventional AOM-treated and ApcMin/+ mice receiving feces from obese individuals showed significantly increased colon tumor formation compared with those receiving feces from control subjects. AOM-treated mice receiving feces from obese (OB-M) exhibited microbiota dysbiosis with enriched potential pathobionts Erysipelotrichaceae bacterium GAM147, Turicibacter sp. H121, Mucinivorans hirudinis, and depleted symbionts Bacteroides vulgatus, Faecalibaculum rodentium, Bifidobacterium spp. and Lactobacillus delbrueckii. The OB-M group also showed altered gut metabolites including elevated phenylacetic acid, and depleted genipin. Moreover, OB-M group showed impaired intestinal barrier function and significant upregulation of pro-inflammatory cytokines and activation of oncogenic Wnt signaling pathway. In conclusion, gut microbiota from obese individuals promotes colorectal carcinogenesis. Microbiota modulation in obese individuals may provide new insight into obesity-driven CRC prevention and therapy. |
| Institute: | The Chinese University of Hong Kong |
| Department: | Medicine and theraputics |
| Last Name: | Kang |
| First Name: | |
| Address: | Rm806, Li Ka Shing Medical Science Building, PWH, Shatin, Hong Kong |
| Email: | kangxing92@163.com |
| Phone: | 93760832 |
Summary of all studies in project PR001397
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002193 | The effects of obesity microbiota produced metabolites on colorectal carcinogenesis in murine models | Mus musculus | The Chinese University of Hong Kong | MS* | 2023-05-18 | 1 | 20 | Uploaded data (282.4M)* |
