Summary of project PR001414

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001414. The data can be accessed directly via it's Project DOI: 10.21228/M8Z42Q This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001414
Project DOI:doi: 10.21228/M8Z42Q
Project Title:Metabolic changes in Alzheimer patient-derived induced neurons and the effects of PKM2 modulation and hypoxia on their metabolic landscape
Project Summary:We have obtained fibroblast cultures from old adult human non-demented control donors and Alzheimer patients (AD). The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. Metabolomic landscape and glucose flux in control versus AD were assessed. Additionally, their response to PKM2 modulation (shikonin 10 ┬ÁM or PKM2 overexpression) and hypoxia (CoDo treatment) were assessed.
Institute:University of Colorado Denver
Laboratory:Lab of Angelo D'Alessandro in collaboration with lab of Jerome Mertens (Univ of Innsbruck)
Last Name:Haines
First Name:Julie
Address:12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA
Email:julie.haines@cuanschutz.edu
Phone:3037243339

Summary of all studies in project PR001414

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST002213 Metabolic changes in Alzheimer patient-derived induced neurons versus non-demented controls Homo sapiens University of Colorado Denver MS 2022-07-25 1 36 Uploaded data (3.5G)*
ST002214 The effects of PKM2 modulation and hypoxia on the metabolic landscape of Alzheimer patient-derived induced neurons Homo sapiens University of Colorado Denver MS 2022-07-25 1 16 Uploaded data (1.2G)*
  logo