Summary of project PR001469
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001469. The data can be accessed directly via it's Project DOI: 10.21228/M8V134 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001469 |
| Project DOI: | doi: 10.21228/M8V134 |
| Project Title: | Integrated metabolic and inflammatory signatures associated with severity, fatality, and recovery of COVID-19 |
| Project Type: | Research |
| Project Summary: | Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed-up after hospital discharge and recovery of acute disease. We used hierarchical community networks to integrate metabolomics profiles with cytokines and markers of inflammation, coagulation, and tissue damage. Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) promotes significant alterations in the plasma metabolome, whose activity varies according to disease severity and correlates with oxygen saturation. Differential metabolism underlying death was marked by amino acids and related metabolites, such as glutamate, tryptophan and oxoproline; and lipids, including progesterone, phosphocholine and lysophosphatidylcholines (lysoPCs). Individuals that recovered from severe disease displayed persistent alterations enriched for metabolism of purines, phosphatidylinositol phosphate and glycolysis. Recovery of mild disease was associated with vitamin E metabolism. Data integration shows that the metabolic response is a hub connecting other biological features during disease and recovery. Infection by SARS-CoV-2 induces concerted activity of metabolic and inflammatory responses that depend on disease severity and collectively predict clinical outcomes of COVID-19. |
| Institute: | Federal University of Goiás |
| Last Name: | Gardinassi |
| First Name: | Luiz Gustavo |
| Address: | R. 235 s/n - Institute of Tropical Pathology and Public Health - Federal University of Goiás |
| Email: | luizgardinassi@ufg.br |
| Phone: | +55 62 3209-6530 |
Summary of all studies in project PR001469
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002291 | Integrated metabolic and inflammatory signatures associated with severity, fatality, and recovery of COVID-19 | Homo sapiens | Federal University of Goiás | MS* | 2022-10-19 | 1 | 232 | Uploaded data (101.1G)* |
