Summary of project PR001490
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001490. The data can be accessed directly via it's Project DOI: 10.21228/M84D89 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001490 |
| Project DOI: | doi: 10.21228/M84D89 |
| Project Title: | Reducing the metabolic burden of rRNA synthesis promotes healthy longevity |
| Project Summary: | Ribosome biogenesis is an anabolic process driven by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). While Pol I activity was previously linked to longevity, the underlying mechanisms were not studied beyond effects on protein translation and downstream proteostasis. Here we used multi-omics and functional tests to show that curtailment of Pol I activity preserves mitochondrial function and lowers ATP expenditure, thereby promoting longevity in Caenorhabditis elegans. Reduced pre-rRNA synthesis also improved longevity and energy homeostasis in Drosophila melanogaster and human cells, respectively. Conversely, the enhancement of pre-rRNA synthesis boosted growth and neuromuscular performance of young nematodes at the cost of accelerated metabolic decline, mitochondrial stress and premature aging. Moreover, restriction of Pol I activity extended lifespan more potently than translational repression, and retained its geroprotective effects when initiated late in life, showcasing moderation of Pol I activity as an effective longevity treatment not limited by aging. |
| Institute: | University of Innsbruck |
| Department: | Michael Popp Institute |
| Last Name: | Koeberle |
| First Name: | Andreas |
| Address: | Mitterweg 24, Innsbruck, Tyrol, 6020, Austria |
| Email: | andreas.koeberle@uibk.ac.at |
| Phone: | +43 512 507 57903 |
| Funding Source: | Leibniz Association, Thüringer Aufbaubank (2019 FGR 0082), Free State of Thuringia (RegenerAging—FSU-I-03/14), Carl-Zeiss-Stiftung (IMPULS), Phospholipid Research Center (AKO-2019-070/2-1) |
| Contributors: | Samim Sharifi, Finja Witt, André Gollowitzer, Oliver Werz, Holger Bierhoff, Maria Ermolaeva |
Summary of all studies in project PR001490
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002324 | Exploration of age-dependent changes of phospholipid profiles in C. elegans depleted of tif-IA and ncl-1 | Caenorhabditis elegans | University of Innsbruck | MS | 2022-11-18 | 1 | 225 | Uploaded data (9.5M)* |
| ST002325 | Determination of changes in free fatty acid levels in C. elegans depleted of tif-IA and ncl-1 | Caenorhabditis elegans | University of Innsbruck | MS | 2022-11-18 | 1 | 45 | Uploaded data (12.4M)* |
| ST002326 | Analysis of age-dependent changes of triacylglycerol species in C. elegans depleted of tif-IA and ncl-1 | Caenorhabditis elegans | University of Innsbruck | MS | 2022-11-18 | 1 | 90 | Uploaded data (6.8M)* |
