Summary of project PR001490

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001490. The data can be accessed directly via it's Project DOI: 10.21228/M84D89 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001490
Project DOI:doi: 10.21228/M84D89
Project Title:Reducing the metabolic burden of rRNA synthesis promotes healthy longevity
Project Summary:Ribosome biogenesis is an anabolic process driven by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). While Pol I activity was previously linked to longevity, the underlying mechanisms were not studied beyond effects on protein translation and downstream proteostasis. Here we used multi-omics and functional tests to show that curtailment of Pol I activity preserves mitochondrial function and lowers ATP expenditure, thereby promoting longevity in Caenorhabditis elegans. Reduced pre-rRNA synthesis also improved longevity and energy homeostasis in Drosophila melanogaster and human cells, respectively. Conversely, the enhancement of pre-rRNA synthesis boosted growth and neuromuscular performance of young nematodes at the cost of accelerated metabolic decline, mitochondrial stress and premature aging. Moreover, restriction of Pol I activity extended lifespan more potently than translational repression, and retained its geroprotective effects when initiated late in life, showcasing moderation of Pol I activity as an effective longevity treatment not limited by aging.
Institute:University of Innsbruck
Department:Michael Popp Institute
Last Name:Koeberle
First Name:Andreas
Address:Mitterweg 24, Innsbruck, Tyrol, 6020, Austria
Email:andreas.koeberle@uibk.ac.at
Phone:+43 512 507 57903
Funding Source:Leibniz Association, Thüringer Aufbaubank (2019 FGR 0082), Free State of Thuringia (RegenerAging—FSU-I-03/14), Carl-Zeiss-Stiftung (IMPULS), Phospholipid Research Center (AKO-2019-070/2-1)
Contributors:Samim Sharifi, Finja Witt, André Gollowitzer, Oliver Werz, Holger Bierhoff, Maria Ermolaeva

Summary of all studies in project PR001490

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST002324 Exploration of age-dependent changes of phospholipid profiles in C. elegans depleted of tif-IA and ncl-1 Caenorhabditis elegans University of Innsbruck MS 2022-11-18 1 225 Uploaded data (9.5M)*
ST002325 Determination of changes in free fatty acid levels in C. elegans depleted of tif-IA and ncl-1 Caenorhabditis elegans University of Innsbruck MS 2022-11-18 1 45 Uploaded data (12.4M)*
ST002326 Analysis of age-dependent changes of triacylglycerol species in C. elegans depleted of tif-IA and ncl-1 Caenorhabditis elegans University of Innsbruck MS 2022-11-18 1 90 Uploaded data (6.8M)*
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