Summary of project PR001493
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001493. The data can be accessed directly via it's Project DOI: 10.21228/M8R403 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001493 |
| Project DOI: | doi: 10.21228/M8R403 |
| Project Title: | Lipidomic profiling indicate protection of hypoxic-ischemic brain injury on neonatal rats ingesting Acer truncatum Bunge oil |
| Project Summary: | Hypoxic ischemic encephalopathy (HIE) has a great impact on the growth and development of newborns. At present, there is a lack of other effective intervention measures except hypothermia therapy, and the effective rate of hypothermia therapy is less than 50%. Using high-throughput metabonomics, we analyzed the serum and brain tissues of 7-day-old HIE mice, mice fed with Acer truncatum Bunge seed oil (ASO) for 30 days and mice fed with their respective ages. All the results revealed that a variety of metabolites changed significantly during injury and repair, and there were many significant enrichment pathways of designed lipid metabolism and neurotrophic factors. Multi-group comparative analysis identified metabolites that may be related to the injury and repair of hypoxic-ischemic encephalopathy, such as glycerol phospholipids and sphingomyelins. Our results suggest that ASO may be a potential special medical food for ischemic hypoxia newborns. |
| Institute: | Bao Feng Key Laboratory of Genetics and Metabolism |
| Last Name: | Chen |
| First Name: | xianyang |
| Address: | Room 525, Floor 5, Building 3, Yard 10, Anxiang Street, Airport Economic Core Zone, Shunyi District, Beijing |
| Email: | cxyibcas@163.com |
| Phone: | 13681398052 |
Summary of all studies in project PR001493
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002329 | Serum metabonomics of rats in sham, HIE, CO and ASO groups were compared. | Rattus norvegicus | Bao Feng Key Laboratory of Genetics and Metabolism | MS* | 2026-01-02 | 1 | 66 | Uploaded data (49.8G)* |
| ST002333 | Brain metabonomics of rats in sham, HIE, CO and ASO groups were compared. | Rattus norvegicus | Bao Feng Key Laboratory of Genetics and Metabolism | MS* | 2026-01-02 | 1 | 66 | Uploaded data (250.2G)* |
| ST002483 | Brain metabonomics of rats in CO and ASO groups from 4500m were compared. | Rattus norvegicus | Bao Feng Key Laboratory of Genetics and Metabolism | MS* | 2026-01-02 | 1 | 32 | Uploaded data (21.5G)* |
