Summary of project PR001512
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001512. The data can be accessed directly via it's Project DOI: 10.21228/M8812G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001512 |
| Project DOI: | doi: 10.21228/M8812G |
| Project Title: | Stool metabolites in peanut allergy |
| Project Summary: | Rising rates of peanut allergy motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk. We performed a longitudinal, multi-center, integrative study of the gut microbiome and metabolome of 122 infants with allergy risk factors but no peanut allergy who were followed through mid childhood. 28.7% of infants developed peanut allergy by mid-childhood. Lower infant gut microbiome diversity was associated with peanut allergy development (P=0.014). Peanut allergy-bound children had different abundance trajectories of Clostridium sensu stricto 1 sp. (FDR=0.015) and Bifidobacterium sp. (FDR=0.033), with butyrate (FDR=0.045) and isovalerate (FDR=0.036) decreasing over time. Metabolites associated with peanut allergy development clustered within the histidine metabolism pathway. Positive correlations between microbiota, butyrate, and isovalerate and negative correlations with histamine marked the peanut allergy free network. The temporal dynamics of the gut microbiome and metabolome in early childhood are distinct for children who develop peanut allergy. |
| Institute: | Icahn School of Medicine at Mount Sinai |
| Last Name: | Bunyavanich |
| First Name: | Supinda |
| Address: | 1 Gustave L. Levy Pl, New York, NY 10029 |
| Email: | supinda.bunyavanich@mssm.edu |
| Phone: | 212-241-5548 |
Summary of all studies in project PR001512
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002355 | Stool short chain fatty acid (SCFA) levels in peanut allergy | Homo sapiens | Icahn School of Medicine at Mount Sinai | MS | 2023-12-08 | 1 | 150 | Uploaded data (2G)* |
| ST002405 | Stool global metabolite levels in peanut allergy (Part 2) | Homo sapiens | Icahn School of Medicine at Mount Sinai | MS | 2023-12-08 | 1 | 40 | Uploaded data (924.8M)* |
