Summary of project PR001514
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001514. The data can be accessed directly via it's Project DOI: 10.21228/M80H6B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001514 |
| Project DOI: | doi: 10.21228/M80H6B |
| Project Title: | Lipidomics of deep-diving pinniped brains |
| Project Summary: | The brain of diving mammals such as the hooded seal (Cystophora cristata) exhibits a remarkable tolerance to low tissue oxygen levels (hypoxia). While neurons of most terrestrial mammals suffer irreversible damage after only short periods of hypoxia, in vitro experiments revealed that neurons of the hooded seal show prolonged functional integrity even in severe hypoxia. As major components of membranes, specific neuronal lipids of diving mammals could contribute to the observed high hypoxia tolerance. Therefore, we analyzed the brain lipidome of deep-diving pinnipeds (Cystophora cristata, Pagophilus groenlandicus) in comparison to terrestrial (non-diving) relatives (Mustela putorius furo, Mus musculus). Furthermore, lipid composition of C. cristata brain tissue was analyzed that was exposed to hypoxia and reoxygenation in vitro. |
| Institute: | University of Hamburg |
| Last Name: | Martens |
| First Name: | Gerrit Alexander |
| Address: | Martin-Luther-King-Platz 3, 20146 Hamburg, Germany |
| Email: | gerrit.alexander.martens@uni-hamburg.de |
| Phone: | +49 40 42838-3934 |
Summary of all studies in project PR001514
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002357 | Comparative lipidomics study of brain samples from deep-diving pinnipeds and terrestrial (non-diving) relatives | Cystophora cristata / Pagophilus groenlandicus / Mustela putorius furo / Mus musculus | University of Hamburg | MS* | 2023-04-12 | 1 | 29 | Uploaded data (6.8G)* |
| ST002358 | Effect of hypoxia and reoxygenation on the juvenile hooded seal brain lipidome | Cystophora cristata | University of Hamburg | MS* | 2023-04-12 | 1 | 35 | Uploaded data (8.2G)* |
| ST002359 | Effect of hypoxia and reoxygenation on the adult hooded seal brain lipidome | Cystophora cristata | University of Hamburg | MS* | 2023-04-12 | 1 | 36 | Uploaded data (5.6G)* |
