Summary of project PR001533
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001533. The data can be accessed directly via it's Project DOI: 10.21228/M8J99C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001533 |
| Project DOI: | doi: 10.21228/M8J99C |
| Project Title: | The 'Omics of Obesity in B-cell Acute Lymphoblastic Leukemia |
| Project Summary: | The obesity pandemic currently affects over 70 million Americans and over 650 million individuals worldwide. In addition to increasing susceptibility to pathogenic infections (e.g., SARS-CoV-2 et al.), obesity promotes the development of many cancer subtypes and increases mortality rates in most cases. It has been demonstrated that, in the context of B-cell acute lymphoblastic leukemia (B-ALL), adipocytes promote multi-drug chemoresistance. Furthermore, it has been demonstrated that B-ALL cells exposed to the adipocyte secretome alter their metabolic states to circumvent chemotherapy-mediated cytotoxicity. To better understand how adipocytes impact the function of human B-ALL cells, we used an untargeted metabolomics mass spectroscopy approach to define adipocyte-induced changes in B-cells. These analyses revealed that the adipocyte secretome directly modulates programs in human B-ALL cells which are associated with metabolism. In all, our data increases our understanding of pathways which may promote chemoresistance in human B-ALL. |
| Institute: | Emory University |
| Department: | Pediatrics |
| Laboratory: | Joshua Chandler, PhD |
| Last Name: | Chandler |
| First Name: | Joshua |
| Address: | 2015 Uppergate Drive NE, Atlanta, GA 30322 |
| Email: | joshua.chandler@emory.edu |
| Phone: | 404-727-3536 |
| Funding Source: | This study was supported by funding for the CURE Childhood Cancer Foundation (Grant No. 001006916), Swim Across America (Grant No. 00103163), The Mark Foundation for Cancer Research (Grant No. 18-031-ASP), Emory University School of Medicine Bridge Funding (Grant No. 00098174), The American Cancer Society and Emory University Winship Cancer Institute Institutional Research Grant (Grant No. IRG-21-137-07-IRG) and the TREC Training Course (Grant No. R25CA203650) all awarded to Curtis J Henry. In additional, funding for Joshua Chandler included NIH R01 NR018666, R56 HL150658, and support from CF@LANTA, a component of Emory University and Children’s Healthcare of Atlanta. |
| Publications: | submitted to JNCI |
| Contributors: | Delaney K. Geitgey, Miyoung Lee, Kirsten A. Cottrill, Matthew B. Kilgore, Joshua D. Chandler, Curtis J. Henry |
Summary of all studies in project PR001533
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002383 | Metabolomics of B-cell Acute Lymphoblastic Leukemia in Response to Adipocyte Conditioned Media | Homo sapiens | Emory University | MS | 2023-06-07 | 1 | 55 | Uploaded data (40.7G)* |
| ST002399 | Metabolomics of Adipocyte-Conditioned Media Compared to Stromal Cell- and Un-conditioned Media | Mus musculus | Emory University | MS | 2023-06-07 | 1 | 48 | Uploaded data (31.1G)* |
