Summary of project PR001568
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001568. The data can be accessed directly via it's Project DOI: 10.21228/M8142B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001568 |
| Project DOI: | doi: 10.21228/M8142B |
| Project Title: | Detection phytochelatins in human urine |
| Project Type: | Untargeted LC-MS metabolomics analysis |
| Project Summary: | The goal of this project was to detect phytochelatins, plant-derived peptides which function as metal chelators, in human urine. Untargeted metabolomics of 143 urine samples from healthy adults was performed. Phytochelatin 2, γE-C-γE-C-G, was detected, and the rest of the urine metabolome was searched for phytochelatins and predicted phytochelatin metabolites which correlated with phytochelatin 2 concentrations. Phytochelatin 2 and associated metabolites were found to correlate with urinary metals, and further experiments were performed provide insight into function of dietary phytochelatins. |
| Institute: | Emory University |
| Department: | Medicine, Pulmonary |
| Laboratory: | Dean Jones |
| Last Name: | Jarrell |
| First Name: | Zachery |
| Address: | 615 Michael St |
| Email: | zjarrel@emory.edu |
| Phone: | 4047275984 |
| Funding Source: | This work was supported by the Emory University Predictive Health Institute, the Woodruff Foundation (Atlanta, GA), National Institutes of Health Grant UL1 TR002378, and National Institute of Environmental Health Sciences Grants R01 ES031980 (YMG), R21 ES031824 (DPJ and YMG), and F32 ES033908 (ZRJ). |
| Contributors: | Zachery R. Jarrell, Ken H. Liu, Kristine K. Dennis, Xin Hu, Greg S. Martin, Dean P. Jones, and Young-Mi Go |
Summary of all studies in project PR001568
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002436 | Discovery of phytochelatins in human urine: Evidence for function in selenium disposition and protection against cadmium | Homo sapiens | Emory University | MS* | 2023-01-25 | 1 | 166 | Uploaded data (17M) |
