Summary of project PR001596
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001596. The data can be accessed directly via it's Project DOI: 10.21228/M8D701 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001596 |
| Project DOI: | doi: 10.21228/M8D701 |
| Project Title: | Linking bacterial metabolites to disease-associated microbes to uncover mechanisms of host-microbial interactions in intestinal inflammation |
| Project Type: | Metabolomic profiling of human fecal and plasma samples and bacterial strains |
| Project Summary: | Understanding the role of the gut microbiome in inflammatory and autoimmune diseases requires the identification of microbial molecular effectors and their link to host pathophysiology. Here, we present a framework to identify and characterize novel microbial metabolites in patient samples and to directly link their production to disease-associated microbes. We applied this approach to investigate the spectrum of disease severity and treatment response in ulcerative colitis (UC) using longitudinal metabolite and strain profiles combined with paired plasma profiles. |
| Institute: | Broad Institute of MIT and Harvard |
| Last Name: | Xavier |
| First Name: | Ramnik |
| Address: | 415 Main Street |
| Email: | rxavier@broadinstitute.org |
| Phone: | 6177147080 |
| Publications: | Schirmer, M., Stražar, M., Avila-Pacheco, J., Rojas-Tapias, D. F., Brown, E. M., Temple, E., Deik, A., Bullock, K., Jeanfavre, S., Pierce, K., Jin, S., Invernizzi, R., Pust, M.-M., Costliow, Z., Mack, D. R., Griffiths, A. M., Walters, T., Boyle, B. M., Kugathasan, S., … Xavier, R. J. (2024). Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2023.12.013 |
| Contributors: | Melanie Schirmer, Martin Strazar, Julian Avila-Pacheco, Daniel F. Rojas-Tapias, Eric Brown, Emily Temple, Subra Kugathasan, Zach Costliow, Hera Vlamakis, Jeff Hyams, Lee Denson, Clary B. Clish, Ramnik J. Xavier |
Summary of all studies in project PR001596
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002470 | Linking bacterial metabolites to disease-associated microbes to uncover mechanisms of host-microbial interactions in intestinal inflammation. Human plasma profiling | Homo sapiens | Broad Institute of MIT and Harvard | MS* | 2024-02-12 | 1 | 89 | Uploaded data (43.1G)* |
| ST002471 | Linking bacterial metabolites to disease-associated microbes to uncover mechanisms of host-microbial interactions in intestinal inflammation. Human stool profiling | Homo sapiens | Broad Institute of MIT and Harvard | MS* | 2024-02-12 | 1 | 91 | Uploaded data (50.2G)* |
| ST002472 | Linking bacterial metabolites to disease-associated microbes to uncover mechanisms of host-microbial interactions in intestinal inflammation. Veillonella parvula cell and media profiling | Veillonella parvula | Broad Institute of MIT and Harvard | MS* | 2024-02-12 | 1 | 37 | Uploaded data (10.8G)* |
| ST002473 | Linking bacterial metabolites to disease-associated microbes to uncover mechanisms of host-microbial interactions in intestinal inflammation. Veillonella parvula media profiling of IBD drug metabolites | Veillonella parvula | Broad Institute of MIT and Harvard | MS* | 2024-02-12 | 1 | 48 | Uploaded data (13.3G)* |
