Summary of project PR001597
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001597. The data can be accessed directly via it's Project DOI: 10.21228/M88H9Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001597 |
| Project DOI: | doi: 10.21228/M88H9Z |
| Project Title: | Retinol Dehydrogenase 10 Reduction Mediated Retinol Metabolism Disorder Promotes Diabetic Cardiomyopathy in Male Mice. |
| Project Summary: | In this study, we identify disordered cardiac retinol metabolism in type 2 diabetic male mice and patients characterized by retinol overload, all-trans retinoic acid deficiency. By supplementing type 2 diabetic male mice with retinol or all-trans retinoic acid, we demonstrate that both cardiac retinol overload and all-trans retinoic acid deficiency promote diabetic cardiomyopathy. Mechanistically, by constructing cardiomyocyte-specific conditional retinol dehydrogenase 10-knockout male mice and overexpressing retinol dehydrogenase 10 in male type 2 diabetic mice via adeno-associated virus, we verify that the reduction in cardiac retinol dehydrogenase 10 is the initiating factor for cardiac retinol metabolism disorder and results in diabetic cardiomyopathy. Therefore, we suggest that the reduction of cardiac retinol dehydrogenase 10 and its mediated disorder of cardiac retinol metabolism is a new mechanism underlying diabetic cardiomyopathy. |
| Institute: | Zhongshan School of Medicine, Sun Yat-sen University |
| Last Name: | Yandi |
| First Name: | Wu |
| Address: | 74, Zhongshan second street |
| Email: | wuyd3@mail2.sysu.edu.cn |
| Phone: | 15622158754 |
| Publications: | Retinol Dehydrogenase 10 Reduction Mediated Retinol Metabolism Disorder Promotes Diabetic Cardiomyopathy in Male Mice. |
| Contributors: | Yandi Wu; Tongsheng Huang; Xinghui Li; Conghui Shen; Honglin Ren; Haiping Wang; Teng Wu; Xinlu Fu; Shijie Deng; Ziqi Feng; Shijie Xiong; Hui Li; Saifei Gao; Zhenyu Yang; Fei Gao; Lele Dong; Jianding Cheng & Weibin Cai |
Summary of all studies in project PR001597
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002474 | Retinol Dehydrogenase 10 Reduction Mediated Retinol Metabolism Disorder Promotes Diabetic Cardiomyopathy in Male Mice. | Mus musculus | Zhongshan School of Medicine, Sun Yat-sen University | MS | 2023-02-13 | 1 | 30 | Uploaded data (509.3K)* |
