Summary of project PR001599
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001599. The data can be accessed directly via it's Project DOI: 10.21228/M8113P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001599 |
| Project DOI: | doi: 10.21228/M8113P |
| Project Title: | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection |
| Project Summary: | While a common symptom of influenza and coronavirus disease 2019 (COVID-19) is fever, its physiological role on host resistance to viral infection remains less clear. Here, we demonstrate that exposure of mice to the high ambient temperature of 36 °C increase host resistance to viral pathogens including influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). High heat-exposed mice increase basal body temperature over 38 °C to enable more bile acids production in a gut microbiota-dependent manner. The gut microbiota-derived deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. Furthermore, the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamster from lethal SARS-CoV-2 infection. Moreover, we demonstrate that certain bile acids are reduced in the plasma of COVID-19 patients who developed moderate I/II disease compared with minor illness group. These findings uncover an unexpected mechanism by which virus-induced high fever increases host resistance to influenza virus and SARS-CoV-2 in a gut microbiota-dependent manner. |
| Institute: | Keio University |
| Last Name: | Fukuda |
| First Name: | Shinji |
| Address: | 246-2 Mizukami, Kakuganji, Tsuruoka-city, Yamagata, 997-0052, Japan |
| Email: | sfukuda@sfc.keio.ac.jp |
| Phone: | +81-235-29-0528 |
Summary of all studies in project PR001599
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002476 | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Mouse) | Mus musculus | Keio University | MS | 2023-03-10 | 2 | 30 | Uploaded data (9.4G)* |
| ST002479 | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Hamster) | Mesocricetus Auratus | Keio University | MS | 2023-03-10 | 2 | 20 | Uploaded data (6.4G)* |
