Summary of project PR001603
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001603. The data can be accessed directly via it's Project DOI: 10.21228/M8H131 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001603 |
| Project DOI: | doi: 10.21228/M8H131 |
| Project Title: | Urolithin A (UroA) acts at CYP1A1/1B1 substrates leading to enhanced aryl hydrocarbon receptor (AHR) activity in vivo |
| Project Summary: | Many AHR ligands are CYP1A1/1B1 substrates, which can result in the rapid clearance within the intestinal tract and other tissues, limiting both the level and duration of AHR activation. This leads to the hypothesis that there are dietary constituents capable of inhibiting CYP1A1/1B1 increasing the half-live of potent AHR ligands. To test this hypothesis, we examined the ability of urolithin A (UroA) to act at CYP1A1/1B1 substrates leading to enhanced AHR activity in vivo. |
| Institute: | Pennsylvania State University |
| Last Name: | FANGCONG |
| First Name: | DONG |
| Address: | 309 Life Sciences Building, State college, PA, 16802, USA |
| Email: | fxd93@psu.edu |
| Phone: | 8146990203 |
Summary of all studies in project PR001603
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002481 | Urolithin A (UroA) acts at CYP1A1/1B1 substrates leading to enhanced aryl hydrocarbon receptor (AHR) activity in vivo | Mus musculus | Pennsylvania State University | MS | 2023-03-02 | 1 | 54 | Uploaded data (4.5G)* |
