Summary of project PR001629
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001629. The data can be accessed directly via it's Project DOI: 10.21228/M84M8C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001629 |
| Project DOI: | doi: 10.21228/M84M8C |
| Project Title: | Untargeted Metabolomics on First Trimester Serum Implicates Metabolic Perturbations Associated with BMI in Development of Hypertensive Disorders: A Discovery Study |
| Project Type: | C18 Reversed-Phase Broad Spectrum Metabolomics |
| Project Summary: | Body mass index (BMI) in early pregnancy is a critical risk factor for hypertensive disorders of pregnancy (HDP). The pathobiology of the interplay between BMI and HDP is not fully understood and represents the focus of this investigation. BMI and 1st-trimester serum samples were obtained from the Global Alliance to Prevent Prematurity and Stillbirth repository for 154 women (105 without HDP and 49 with HDP). Metabotyping was conducted using ultra-high-performance liquid-chromatography high-resolution mass spectrometry (UHPLC HR-MS). Regression models were used to determine metabolites and pathway perturbations associated with BMI in women with and without HDP, and to determine metabolites and pathway perturbations associated with HDP for women in categories of obese, overweight, and normal weight based on the 1st trimester BMI. This study will lay the groundwork for larger studies of predictive markers and biological pathways leading to infant morbidity and mortality. |
| Institute: | Tulane University |
| Department: | Department of Epidemiology |
| Last Name: | Harville |
| First Name: | Emily |
| Address: | Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2001, New Orleans, LA, 70112, USA. |
| Email: | harville@tulane.edu |
| Phone: | 504-988-7327 |
| Funding Source: | R21 |
Summary of all studies in project PR001629
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002533 | Untargeted Metabolomics on First Trimester Serum Implicates Metabolic Perturbations Associated with BMI in Development of Hypertensive Disorders: A Discovery Study | Homo sapiens | University of North Carolina at Chapel Hill | MS* | 2023-07-06 | 1 | 178 | Uploaded data (14.6G)* |
