Summary of project PR001637
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001637. The data can be accessed directly via it's Project DOI: 10.21228/M83M7P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001637 |
| Project DOI: | doi: 10.21228/M83M7P |
| Project Title: | The metabolomics analysis of Methionine restriction |
| Project Type: | targeted metabolomics data |
| Project Summary: | Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S. cerevisiae that MR relays a signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic mitochondria to nitrogenic anabolism.In particular, decreases in cellular SAM constrain lipoate metabolism and protein lipoylation required for the operation of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete glucose oxidation with an exit of acetyl-CoA and alpha-ketoglutarate from the TCA cycle to the syntheses of amino acids, such as arginine and leucine. This mitochondrial SAM-induced response, namely mitoSIR, promotes cell fitness through the coordination of mitochondrial fuel metabolism with the nitrogenic synthesis of amino acids. |
| Institute: | Zhejiang University |
| Department: | Life Sciences Institute |
| Last Name: | Cunqi |
| First Name: | Ye |
| Address: | 866 Yuhangtang Rd, Hangzhou 310058, P.R. China |
| Email: | yecunqi@zju.edu.cn |
| Phone: | 15267181160 |
Summary of all studies in project PR001637
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002541 | Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids (Part 1) | Saccharomyces cerevisiae | ZheJiang University | MS | 2023-04-21 | 1 | 15 | Uploaded data (3.8M)* |
| ST002542 | Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids (Part 2) | Saccharomyces cerevisiae | ZheJiang University | MS | 2023-04-21 | 1 | 27 | Uploaded data (6.6M)* |
