Summary of project PR001639
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001639. The data can be accessed directly via it's Project DOI: 10.21228/M8V41D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001639 |
| Project DOI: | doi: 10.21228/M8V41D |
| Project Title: | Metabolomic study on the chronic Toxoplasma gondii infection in mice. |
| Project Type: | Untargeted MS |
| Project Summary: | Cachexia is a life-threatening disease characterized by chronic, inflammatory muscle wasting and systemic metabolic impairment. Despite its high prevalence, there are no efficacious therapies for cachexia. Mice chronically infected with the protozoan parasite Toxoplasma gondii represent a novel animal model recapitulating the chronic kinetics of cachexia. To understand how perturbations to metabolic tissue homeostasis influence circulating metabolite availability we used mass spectrometry analysis. Despite the significant reduction in circulating triacylglycerides, nonesterified fatty acids, and glycerol, sphingolipid long-chain bases and a subset of phosphatidylcholines (PCs) were significantly increased in the sera of mice with T. gondii infection-induced cachexia. In addition, the TCA cycle intermediates alpha-ketoglutarate, 2- hydroxyglutarate, succinate, fumarate, and malate were highly depleted in cachectic mouse sera. Sphingolipids and their de novo synthesis precursors PCs are the major components of the mitochondrial membrane and regulate mitochondrial function consistent with a causal relationship in the energy imbalance driving T. gondii-induced chronic cachexia. |
| Institute: | University of Virginia |
| Last Name: | Feng |
| First Name: | Tzu-Yu |
| Address: | 345 Crispell Dr. |
| Email: | ttf4ye@virginia.edu |
| Phone: | 702-217-4454 |
Summary of all studies in project PR001639
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002544 | Metabolomic study on the chronic Toxoplasma gondii infection in mice. | Mus musculus | University of Virginia | MS | 2023-04-20 | 1 | 16 | Uploaded data (164.4M)* |
| ST002545 | Lipidomic profile of Toxoplasma gondii-infected mice (Positive mode MS) | Mus musculus | University of Virginia | MS* | 2023-04-20 | 1 | 16 | Uploaded data (3.7G)* |
| ST002546 | Lipidomic profile of Toxplasma gondii-infected mice (Negative mode MS) | Mus musculus | University of Virginia | MS* | 2023-04-20 | 1 | 16 | Uploaded data (3.7G)* |
| ST002549 | Lipidomic analysis of serum from mice with Toxoplasma gondii infection | Mus musculus | University of Virginia | MS | 2023-04-20 | 1 | 18 | Uploaded data (57.2M)* |
