Summary of project PR001647

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001647. The data can be accessed directly via it's Project DOI: 10.21228/M8T413 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001647
Project DOI:doi: 10.21228/M8T413
Project Title:Ethnicity-Specific Differences in Ovarian Cancer Metabolic Signatures
Project Type:Cell line analysis
Project Summary:Ovarian cancer is a leading cause of cancer-related deaths among women worldwide. Cancer cell metabolism plays a critical role in tumor growth and progression, and metabolic alterations in cancer cells have been implicated in treatment resistance. In this study, we performed metabolomic analysis using ovarian cancer cells derived from patients in the United States and Korea. Our results reveal significant ethnic-specific differences in the metabolic signatures of ovarian cancer cells, with differential regulation of metabolites derived from glycolytic pathways, lipid metabolism, and microbiome modified metabolites. These findings have important therapeutic implications, as differences in ovarian cancer metabolism between ethnic groups may influence treatment response and resistance. Targeting the unique metabolic signatures of ovarian cancer cells based on ethnic specificity may improve the effectiveness of precision medicine approaches in the treatment of ovarian cancer. This study highlights the potential for personalized and targeted therapeutic options based on the tumor metabolome and ethnic background of the patient. Overall, our results suggest that investigating ethnic-specific differences in cancer metabolism is critical for developing effective and personalized cancer therapies. The identification of unique metabolic signatures in ovarian cancer cells based on ethnic specificity provides a promising avenue for improving treatment outcomes and advancing the field of precision medicine in ovarian cancer.
Institute:University of Oklahoma Health Sciences Center
Department:Cell Biology
Laboratory:Danny N Dhanasekaran
Last Name:Jayaraman
First Name:Muralidharan
Address:975 NE 10th street BRC1468 Oklahoma City OK 73104
Phone:405-271-8001 x30492
Contributors:Danny N. Dhanasekaran, Jihee Ha, Yong Sang Song

Summary of all studies in project PR001647

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002555 Ethnicity-Specific Differences in Ovarian Cancer Metabolic Signatures Homo sapiens University of Oklahoma Health Sciences Center MS 2023-04-25 1 48 Not available