Summary of project PR001665
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001665. The data can be accessed directly via it's Project DOI: 10.21228/M8GQ6R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001665 |
| Project DOI: | doi: 10.21228/M8GQ6R |
| Project Title: | Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo |
| Project Summary: | We previously showed that replenishing Zn in Zn-deficient rats and supplementing Zn in Zn-sufficient rats inhibit the development of esophageal squamous cell carcinoma (ESCC) (1) and tongue squamous cell carcinoma (2). To determine if Zn has anticancer activity in established ESCC, we performed a 33-day Zn treatment study in 31 ESCC-bearing ZD male rats with 85% ESCC incidence (designated Zn-untreated) that were generated in a 20-wk Zn deficiency-promoted, N-nitrosomethylbenzylamine (NMBA)-induced ESCC experiment (3). The ESCC-bearing Zn-untreated male rats demonstrated oncogenic miR-31 and -21 upregulation (3, 4) and human ESCC-associated metabolic changes (3), with decreased levels of glycolytic intermediates and increased levels of anabolic/biosynthetic intermediates, changes pointing to a classic cancer cell remodeling of energy and nucleoside metabolism (5). The 31 ESCC-bearing Zn-untreated rats were randomized into two groups, viz Zn-untreated (n = 10) and Zn-treated (n = 21). While Zn-untreated rats continued on ZD diet and deionized water, Zn-treated rats were given deionized water supplemented with 25 ppm Zn as Zn gluconate (2) and paired-fed a ZS diet to Zn-untreated rats. This study was concluded after 33 days of Zn medication. We found that Zn therapy reduced ESCC incidence from 90 to 43%, a drop of 47%. We then determined if Zn intervention, that reduced ESCC incidence, would induce metabolic changes to reverse the ESCC-associated metabolome (3). |
| Institute: | West Coast Metabolomics Center |
| Last Name: | Pedrosa |
| First Name: | Diego |
| Address: | 451 Health Science Dr, Davis, CA, 95616, USA |
| Email: | dpedrosa@ucdavis.edu |
| Phone: | (530) 752-8129 |
Summary of all studies in project PR001665
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002585 | Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo | Rattus norvegicus | West Coast Metabolomics Center | MS | 2023-05-15 | 1 | 22 | Uploaded data (241.2M)* |
