Summary of project PR001665

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001665. The data can be accessed directly via it's Project DOI: 10.21228/M8GQ6R This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001665
Project DOI:doi: 10.21228/M8GQ6R
Project Title:Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo
Project Summary:We previously showed that replenishing Zn in Zn-deficient rats and supplementing Zn in Zn-sufficient rats inhibit the development of esophageal squamous cell carcinoma (ESCC) (1) and tongue squamous cell carcinoma (2). To determine if Zn has anticancer activity in established ESCC, we performed a 33-day Zn treatment study in 31 ESCC-bearing ZD male rats with 85% ESCC incidence (designated Zn-untreated) that were generated in a 20-wk Zn deficiency-promoted, N-nitrosomethylbenzylamine (NMBA)-induced ESCC experiment (3). The ESCC-bearing Zn-untreated male rats demonstrated oncogenic miR-31 and -21 upregulation (3, 4) and human ESCC-associated metabolic changes (3), with decreased levels of glycolytic intermediates and increased levels of anabolic/biosynthetic intermediates, changes pointing to a classic cancer cell remodeling of energy and nucleoside metabolism (5). The 31 ESCC-bearing Zn-untreated rats were randomized into two groups, viz Zn-untreated (n = 10) and Zn-treated (n = 21). While Zn-untreated rats continued on ZD diet and deionized water, Zn-treated rats were given deionized water supplemented with 25 ppm Zn as Zn gluconate (2) and paired-fed a ZS diet to Zn-untreated rats. This study was concluded after 33 days of Zn medication. We found that Zn therapy reduced ESCC incidence from 90 to 43%, a drop of 47%. We then determined if Zn intervention, that reduced ESCC incidence, would induce metabolic changes to reverse the ESCC-associated metabolome (3).
Institute:West Coast Metabolomics Center
Last Name:Pedrosa
First Name:Diego
Address:451 Health Science Dr, Davis, CA, 95616, USA
Phone:(530) 752-8129

Summary of all studies in project PR001665

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002585 Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo Rattus norvegicus West Coast Metabolomics Center MS 2023-05-15 1 22 Uploaded data (241.2M)*