Summary of project PR001666
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001666. The data can be accessed directly via it's Project DOI: 10.21228/M8C13S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001666 |
| Project DOI: | doi: 10.21228/M8C13S |
| Project Title: | Metabolic profile of individuals with and without type 2 diabetes from sub-Saharan Africa |
| Project Summary: | Epidemiological data predicts that Sub-Saharan Africa will have the largest increase in type 2 diabetes (T2D) prevalence over the next two decades. Metabolomics studies have identified biomarkers that could improve T2D diagnosis and follow-up. However, no studies have characterized the metabolome of people from Sub-Saharan Africa. Plasma samples from Senegalese individuals with T2D (n=31) or without T2D (n=34) were compared using measures of oxidative stress damage and plasma antioxidant enzyme activity, and mass-spectrometry-based lipidomics and metabolomics analyses. Results showed that glucose, lactate, and TCA metabolites (fumarate, malate, and succinate) were increased in the T2D group, suggesting alterations in glycolysis and mitochondrial dysfunction. Several amino acids (leucine, isoleucine, valine, and tryptophan) and long-to very-long-chain fatty acids were higher in the T2D group. Finally, elevated levels of ketone bodies and acylcarnitines were observed along with increased levels of oxidative stress damage and anti-oxidant activity. In conclusion, the T2D group exhibited modifications in metabolites previously shown to be associated with T2D risk in populations from other areas of the world. Future studies should seek to test whether these metabolites could be used as predictors for T2D-related complications in people from Sub-Saharan Africa. |
| Institute: | University of Colorado Anschutz Medical Campus |
| Last Name: | Nemkov |
| First Name: | Travis |
| Address: | 12801 E 17th Avenue, RC-1 South, Rm 9121, Aurora, CO, 80045, USA |
| Email: | travis.nemkov@cuanschutz.edu |
| Phone: | 303-724-3253 |
Summary of all studies in project PR001666
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002681 | Non-T2D vs T2D | Homo sapiens | University of Colorado Anschutz Medical Campus | MS | 2023-10-26 | 1 | 130 | Uploaded data (750.8M)* |
