Summary of project PR001672

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001672. The data can be accessed directly via it's Project DOI: 10.21228/M8KH8C This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001672
Project DOI:doi: 10.21228/M8KH8C
Project Title:A stress-responsive brain-gut metabolic axis instructs intestinal cell lineage commitment
Project Type:serum
Project Summary:The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-3-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities.
Institute:China Pharmaceutical University
Last Name:yuanlong
First Name:hou

Summary of all studies in project PR001672

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST002701 Mouse serum metabolomics Mus musculus China Pharmaceutical University MS 2023-05-26 1 24 Uploaded data (279M)*