Summary of project PR001688
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001688. The data can be accessed directly via it's Project DOI: 10.21228/M8HH7C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001688 |
| Project DOI: | doi: 10.21228/M8HH7C |
| Project Title: | Gut genomic and metabolic signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis |
| Project Summary: | There are limited data on the diagnostic accuracy of gut microbial signatures for predicting hepatic decompensation in patients with cirrhosis. The aim of this study is to determine whether a stool genomic and metabolic signature accurately detects hepatic decompensation and mortality risk in cirrhosis secondary to nonalcoholic fatty liver disease (NAFLD). Based on the severity of cirrhosis, cirrhosis patients can be categorized as compensated or decompensated. Shotgun metagenomic sequencing was performed on fecal samples collected from a prospective cohort of adults with NAFLD-related cirrhosis. The signatures were further validated with a metabolomic study on fecal and serum samples. Finally, we developed a Random Forest machine learning algorithm to make predictions on hepatic decompensation and mortality in NAFLD-related cirrhosis. Here we uploaded the metabolomics study data of serum samples in LC-MS/MS analysis. |
| Institute: | University of British Columbia |
| Department: | Chemistry |
| Last Name: | Zhao |
| First Name: | Tingting |
| Address: | 2036 Main Mall, Vancouver, V6T 1Z1 |
| Email: | tingzhao@chem.ubc.ca |
| Phone: | 6048221253 |
| Publications: | Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. Aliment Pharmacol Ther. 2022;56:1475–1485. DOI: 10.1111/apt.17236 |
Summary of all studies in project PR001688
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002722 | Cirrhosis-related metabolomics study | Homo sapiens | University of British Columbia | MS* | 2023-06-12 | 1 | 22 | Uploaded data (76.3M)* |
