Summary of project PR001693
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001693. The data can be accessed directly via it's Project DOI: 10.21228/M8VT66 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001693 |
| Project DOI: | doi: 10.21228/M8VT66 |
| Project Title: | Role of AICARP, an endogenous AMPK activator, in improved endurance capacity in diabetic mice during SGLT2 inhibition. |
| Project Type: | Wide targeted metabolomics & lipidomics |
| Project Summary: | Diabetes is often associated with increased risk of deleterious muscle mass and function or sarcopenia, thus leading to physical inactivity and metabolic disorders. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an oral antidiabetic drug that promotes urinary excretion of glucose in the renal proximal tubules. However, how SGLT2 inhibition affects the skeletal muscle function in patients with diabetes remains elusive. Here, we examined the differential effect of CANA on the oxidative soleus and glycolytic EDL muscles from genetically obese diabetic db/db mice. |
| Institute: | Medical Institute of Bioregulation, Kyushu University |
| Department: | Metabolomics |
| Laboratory: | Bamba lab. |
| Last Name: | Takahashi |
| First Name: | Masatomo |
| Address: | Maidashi 3-1-1, Higashi-ku, Fukuoka, Fukuoka, 8128582, Japan |
| Email: | m-takahashi@bioreg.kyushu-u.ac.jp |
| Phone: | 0926426171 |
| Publications: | https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.13350 |
Summary of all studies in project PR001693
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002729 | Improved Endurance Capacity of Diabetic Mice during SGLT2 Inhibition: Potential Role of AICARP, an Endogenous AMPK Activator. | Mus musculus | Medical Institute of Bioregulation, Kyushu University | MS | 2023-11-09 | 1 | 36 | Uploaded data (68.8G)* |
