Summary of project PR001696
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001696. The data can be accessed directly via it's Project DOI: 10.21228/M8GM73 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001696 |
| Project DOI: | doi: 10.21228/M8GM73 |
| Project Title: | Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus |
| Project Type: | Clinical study |
| Project Summary: | Background. Patients with systemic lupus erythematosus (SLE) exhibit a high risk for cardiovascular diseases (CVD) which is not fully explained by the classical Framingham risk factors. SLE is characterized by major metabolic alterations which can contribute to the elevated prevalence of CVD. In order to address this hypothesis, a comprehensive analysis of the circulating metabolome and lipidome was conducted in a large cohort of 211 women with SLE who underwent a multi-detector computed tomography scan for quantification of coronary artery calcium (CAC), a robust predictor of coronary heart disease (CHD). Results. Beyond traditional risk factors, including age and hypertension, disease activity and duration were independent risk factor for developing CAC in women with SLE. The presence of coronary calcium was associated with major alterations of circulating lipidome dominated by an elevated abundance of ceramides with very long chain fatty acids. Alterations in multiple metabolic pathways, including purine, arginine and proline metabolism, and microbiota-derived metabolites, were also associated with CAC in women with SLE. Backward stepwise logistic regression models of lipidomic and metabolomic variables were used to develop prognostic scores. Strikingly, combining metabolic and lipidomic variables with clinical and biological parameters markedly improved the prediction (area under the curve: 0.887, P<0.001) of the presence of coronary calcium in women with SLE. Conclusion. The present study uncovers the contribution of disturbed metabolism to the presence of coronary artery calcium and the prediction of CHD in SLE. Identification of novel lipid and metabolite biomarkers may help stratifying patients for reducing CVD morbidity and mortality in SLE. |
| Institute: | INSERM |
| Last Name: | Lhomme |
| First Name: | Marie |
| Address: | Bd de l'hopital, Paris, Ile de France, 75013, France |
| Email: | m.lhomme@ihuican.fr |
| Phone: | +33184827767 |
Summary of all studies in project PR001696
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002732 | Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus | Homo sapiens | INSERM | MS | 2023-06-25 | 1 | 207 | Uploaded data (39.4M)* |
