Summary of project PR001703
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001703. The data can be accessed directly via it's Project DOI: 10.21228/M8K99P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001703 |
| Project DOI: | doi: 10.21228/M8K99P |
| Project Title: | Innate immune and metabolic signaling retain damaged mitochondria at cell membranes for mitoxyperilysis |
| Project Summary: | Innate immune activation coupled with metabolic disruptions play critical roles in many diseases, often leading to mitochondrial dysfunction and oxidative stress that drive pathogenesis. However, mechanistic regulation under these conditions remains poorly defined. Here, we report a distinct lytic cell death mechanism induced by innate immune signaling and metabolic disruption, independent of caspase activity and previously described pyroptosis, PANoptosis, necroptosis, ferroptosis, and oxeiptosis. Instead, mitochondria undergoing BAX/BAK1/BID-dependent oxidative stress maintained prolonged plasma membrane contact, leading to local oxidative damage, a process we termed mitoxyperiosis. This process then caused membrane lysis and cell death, mitoxyperilysis. mTORC2 regulated the cell death, and mTOR inhibition restored cytoskeletal activity for lamellipodia retractions to mobilize mitochondria away from the membrane, preserving integrity. Activating this pathway in vivo regressed tumors in an mTORC2-dependent manner. Overall, our results identify a lytic cell death modality in response to the synergism of innate immune signaling and metabolic disruption. |
| Institute: | St Jude Children's Research Hospital |
| Last Name: | Wang |
| First Name: | Yaqiu |
| Address: | 262 Danny Thomas Pl, Memphis, Tennessee, 38105, USA |
| Email: | yaqiu.wang@stjude.org |
| Phone: | +1-901-595-3477 |
Summary of all studies in project PR001703
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002738 | Innate immune and metabolic signaling retain damaged mitochondria at cell membranes for mitoxyperilysis | Mus musculus | St Jude Children's Research Hospital | MS* | 2025-11-28 | 1 | 26 | Uploaded data (410.6M)* |
