Summary of project PR001750
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001750. The data can be accessed directly via it's Project DOI: 10.21228/M8H71B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001750 |
| Project DOI: | doi: 10.21228/M8H71B |
| Project Title: | Metabolic abnormalities in the bone marrow of the newly weaned offspring of obese mothers |
| Project Summary: | Obese mothers predispose their babies to develop metabolic disorders and obesity before they are even born. The study used a mouse model of maternal high-fat diet-induced obesity that recapitulates cardiovascular and metabolic abnormalities seen in humans born to obese mothers. to compare the metabolic characteristics of bone marrow cells in newly weaned mice. The results showed that the bone marrow of offspring born to mothers on a high-fat diet primarily used glucose through OXPHOS, and presented decreased amino acid metabolism. These metabolic changes were observed in the bone marrow of the offspring at a very young age, before any symptomatic metabolic disease was present. |
| Institute: | Oregon Health and Science University |
| Department: | Knight Cardiovascular Institute |
| Laboratory: | Maloyan laboratory |
| Last Name: | Maloyan |
| First Name: | Alina |
| Address: | 3181 S.W. Sam Jackson Park Road, Portland, Oregon, 97239-3098, USA |
| Email: | maloyan@ohsu.edu |
| Phone: | 503-494-0012 |
| Funding Source: | NIH HD099367, NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997, www.mmpc.org) under the MICROMouse Program, grants DK076169 |
Summary of all studies in project PR001750
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002803 | Early life metabolic abnormalities in the bone marrow of the offspring of obese mothers | Mus musculus | Oregon Health and Science University | MS | 2024-06-18 | 1 | 20 | Uploaded data (229.8M)* |
