Summary of project PR001757

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001757. The data can be accessed directly via it's Project DOI: 10.21228/M8M13Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR001757
Project DOI:doi: 10.21228/M8M13Z
Project Title:Functional GAS2 studies
Project Type:GC-MS qualitative analysis
Project Summary:Liu et al. recently reported the characterization of Arabidopsis thaliana GAS2 (Gain of Function in ABA-modulated Seed Germination 2), which was described as an enzyme that catalyzes the stereospeci?c hydration of GA12 to produce GA12 16, 17-dihydro-16?-ol (DHGA12). A second paper describes the conversion of GA12 to an unidentified product by GAS2 and also reports that this enzyme does not convert ABA. However, as previously reported, we did not find any conversion of [17-14C]-labeled or [1-,7-,12-,18-14C4]-labeled GA12 by GAS2. Instead, we present here data showing that the recombinant GAS2 enzyme is capable of catabolising abscisic acid (ABA) to phaseic acid (PA) and further to a second product, putative 8’-carboxy-ABA (compound A; Fig. 1a).
Institute:Technische Universität Braunschweig
Department:Biochemie und Physiologie der Pflanzen
Laboratory:AG Lange
Last Name:Lange
First Name:Theo
Address:Mendelssohnstr. 4
Email:theo.lange@tu-bs.de
Phone:00495313915880
Contributors:Nadiem Atiq, Maria João Pimenta Lange

Summary of all studies in project PR001757

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST002810 GAS2 encodes a 2-oxoglutarate dependent dioxygenase involved in ABA catabolism Arabidopsis thaliana Technische Universität Braunschweig MS 2023-10-11 1 35 Uploaded data (1.1G)*
  logo