Summary of project PR001758
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001758. The data can be accessed directly via it's Project DOI: 10.21228/M8GB0P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001758 |
| Project DOI: | doi: 10.21228/M8GB0P |
| Project Title: | Metabolomics panel associated with cystic fibrosis-related diabetes towards biomarker discovery |
| Project Summary: | Background: The most prevalent comorbidity among cystic fibrosis (CF) patients is cystic fibrosis-related diabetes (CFRD). CFRD has been linked to one of the worse clinical outcomes and higher mortality. Improved clinical results have been related to earlier diagnosis and treatment of CFRD. Therefore, the present study aimed to investigate the metabolome of human serum of patients with CFRD. This might aid in identifying novel biomarkers linked with the pathophysiology of CFRD and its diagnosis. Methods: The liquid chromatography–high-resolution mass spectrometry (LC–HRMS) metabolomics approach was utilized for serum samples from patients with CF (n= 36) and healthy control (n=36). Among the CF group, nine patients were with CFRD and 27 were non-CFRD (nCFRD). Results: A total of 2328 metabolites were significantly altered in CF compared to the healthy control. Among those, 799 significantly dysregulated metabolites were identified between CFRD and nCFRD. Arachidonic acid (AA), ascorbate, and aldarate metabolism were the most common metabolic pathways dysregulated in CF. L-homocysteic acid (L-HCA) levels were significantly reduced in CF and CFRD compared to control and nCFRD, respectively. In addition, gamma-glutamylglycine and L-5-hydroxytryptophan (5-HTP) had the highest discrimination between CFRD and nCFRD with AUC (0.716 and 0.683, respectively). Conclusions: These biomarkers might serve as diagnostic biomarkers and aid in understanding potential metabolic changes linked to CF and CFRD. |
| Institute: | King Faisal Specialist Hospital and Research Centre (KFSHRC) |
| Last Name: | Al Mogren |
| First Name: | Maha |
| Address: | Zahrawi Street, Al Maather, Riyadh 11211, Saudi Arabia |
| Email: | mmogren@kfshrc.edu.sa |
| Phone: | 966541205332 |
Summary of all studies in project PR001758
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002811 | Metabolomics panel associated with cystic fibrosis-related diabetes towards biomarker discovery | Homo sapiens | King Faisal Specialist Hospital and Research Centre (KFSHRC) | MS* | 2024-08-05 | 1 | 72 | Uploaded data (187.4G)* |
