Summary of project PR001760
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001760. The data can be accessed directly via it's Project DOI: 10.21228/M86T5X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001760 |
| Project DOI: | doi: 10.21228/M86T5X |
| Project Title: | Effects of acute cold exposure on mouse metabolome |
| Project Summary: | Cold-induced thermogenesis is widely studied as a potential avenue to treat obesity, but a thorough understanding of the metabolic changes driving thermogenesis is lacking. We analyzed mouse plasma and tissue samples from fasted mice housed at room temperature or acutely exposed to 4°C. First, C57BL/6 mice (n=41) were divided into 2 groups (n=20-21 per group) and underwent surgery to implant an indwelling arterial catheter. Mice originally housed at room temperature were housed without food for 6 hours at room temperature or 4°C, after which blood was collected from the arterial catheter and centrifuged, and plasma was collected for metabolomic analyses. Second, C57BL/6 mice (n=12) were divided into 2 groups (n=6 per group) and housed without food for 6 hours at room temperature or 4°C. Mice were euthanized, and tissues (brown adipose tissue, heart, liver, quadricepts muscle, diaphragm, and gonadal-white adipose tissue) were collected, freeze-clamped in liquid nitrogen, and used for metabolomic analyses. Overall our data detail a coordinated and broad metabolic response governing the thermogenic response to acute cold exposure in mice. |
| Institute: | University of Pennsylvania |
| Department: | Medicine |
| Laboratory: | Arany Lab |
| Last Name: | Marc |
| First Name: | Bornstein |
| Address: | 3400 Civic Center Blvd (Smilow 11-187) |
| Email: | marc.bornstein@pennmedicine.upenn.edu |
| Phone: | 7742796684 |
Summary of all studies in project PR001760
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002813 | Effects of acute cold exposure on mouse metabolome | Mus musculus | University of Pennsylvania | MS | 2023-10-05 | 1 | 236 | Uploaded data (6.1G)* |
