Summary of project PR001783
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001783. The data can be accessed directly via it's Project DOI: 10.21228/M87M7X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001783 |
| Project DOI: | doi: 10.21228/M87M7X |
| Project Title: | Lipidomics for linked and unlinked CD1 proteins |
| Project Summary: | The cellular CD1 system binds lipid antigens for display to T cells. Here we developed a lipidomics platform that detected > 2000 distinct lipids in cellular CD1 complexes, demonstrating a broad display of self-sphingolipids and phospholipids to T cells. The four types of human CD1 antigen presenting molecules show differing lipid capture motifs based on the length and chemical structures of lipids bound, pointing to general self-lipid capture mechanisms. For CD1a and CD1d, lipid size matches CD1 cleft volume, whereas CD1b shows a nearly universal size mismatch with its ligands, which results from the uniform seating of two small lipids within its large cleft. Further, the list of compounds that comprise the assembled CD1 lipidomes provides a resource for matching to bioactive lipids from other fields of research and supports the ongoing discovery of lipid blockers and antigens for T cells. |
| Institute: | Brigham and Women's Hospital |
| Last Name: | Huang |
| First Name: | Shouxiong |
| Address: | 251 Kettering Laboratory Complex, 160 Panzeca Way, Cincinnati, OH |
| Email: | shouxiong.huang@uc.edu |
| Phone: | 5135587572 |
Summary of all studies in project PR001783
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002848 | Lipidomics for linked CD1 proteins | Homo sapiens | Brigham and Women's Hospital | MS* | 2023-11-10 | 1 | 18 | Uploaded data (3.5G)* |
| ST002849 | Lipidomics for unlinked CD1 proteins | Homo sapiens | Brigham and Women's Hospital | MS* | 2023-11-10 | 1 | 18 | Uploaded data (3.6G)* |
