Summary of project PR001785
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001785. The data can be accessed directly via it's Project DOI: 10.21228/M8043D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001785 |
| Project DOI: | doi: 10.21228/M8043D |
| Project Title: | A genetic-metabolic axis confers liver-metastatic organotropism |
| Project Summary: | Transcriptomic and metabolomic analyses in animals revealed distinct metabolic adaptations, particularly related to the TCA cycle and OxPhos, specific to liver metastases compared to concurrent lung metastases. This finding was substantiated by analyzing RNA-seq data from a considerable number of patient metastases across various cancer types. Further analysis of exome/RNA-seq data from melanoma patients indicated more frequent PIK3CA mutations, lower transcript levels of PIP4K2C, and enrichment of TCA cycle and OxPhos pathways in liver metastases. |
| Institute: | Columbia University - Medical Center |
| Department: | Department of Medicine |
| Laboratory: | Division of Hematology/Oncology |
| Last Name: | Izar |
| First Name: | Benjamin |
| Address: | Columbia University Irving Medical Center, New York, NY, USA |
| Email: | bi2175@cumc.columbia.edu |
| Phone: | 0123456789 |
Summary of all studies in project PR001785
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002851 | Metabolic caracterization of liver metastasis organotropism | Mus musculus | Columbia University | MS* | 2023-10-02 | 1 | 30 | Uploaded data (3.5G)* |
