Summary of project PR001814
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001814. The data can be accessed directly via it's Project DOI: 10.21228/M87D9M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR001814 |
| Project DOI: | doi: 10.21228/M87D9M |
| Project Title: | MINCH causes metabolic rewiring towards lipid accumulation and adipogenesis |
| Project Summary: | Humans are ubiquitously exposed to plastic additives, including plasticizers. There is growing evidence that exposure to certain plasticizers is associated with the development of obesity due to their metabolism-disrupting properties. Following the restriction of the use of the phthalate plasticizer di-(2-ethylhexyl) phthalate (DEHP) due to its adverse health effects, it has been replaced by new substitutes such as the plasticizer diisononylcyclohexane-1,2-dicarboxylate (DINCH). Despite recent studies suggesting that the primary metabolite monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) promotes human adipocyte differentiation, the adipogenic properties of MINCH remain controversial. Because the metabolome largely reflects the molecular phenotype and is sensitive to perturbation by external factors, we used targeted metabolomics to investigate the effects of DINCH and MINCH on key metabolic pathways of adipocytes. Analysis of central carbon metabolism is particularly relevant because it provides cellular energy through the degradation of organic compounds and metabolic precursors for anabolic functions that are critical for adipocyte function, such as de novo lipogenesis. The project consists of three main studies: analysis of the effects of DINCH and MINCH on central carbon metabolism of human SGSB cells, analysis of the insulin response of DINCH- and MINCH-treated SGSB cells, and analysis of the effects of DINCH and MINCH on central carbon metabolism of human SGSB cells in the presence of the PPARG inhibitor GW9662. |
| Institute: | Helmholtz Centre for Environmental Research |
| Last Name: | Engelmann |
| First Name: | Beatrice |
| Address: | Permoserstr. 15 |
| Email: | beatrice.engelmann@ufz.de |
| Phone: | 00493412351099 |
Summary of all studies in project PR001814
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST002919 | Short-term metabolic insulin response of DINCH- and MINCH-treated cells | Homo sapiens | Helmholtz Centre for Environmental Research | MS | 2023-11-01 | 1 | 100 | Uploaded data (15M)* |
| ST002920 | Possible PPARG-independent effects of DINCH and MINCH on central carbon metabolism | Homo sapiens | Helmholtz Centre for Environmental Research | MS | 2023-11-01 | 1 | 32 | Uploaded data (17.5M)* |
| ST002922 | Effects of DINCH and MINCH on adipocyte metabolism of human SGBS cells. | Homo sapiens | Helmholtz Centre for Environmental Research | MS | 2023-11-03 | 1 | 87 | Uploaded data (16.7M)* |
